Several animal models have been used for in vivo and in vitro shoulder research. In vitro models, consisting of cadaveric specimens, are useful in providing basic understanding of the functioning of the shoulder and for biomechanical experiments. In vivo models provide the means to model living phenomena, such as tendon healing process, tendinopathy, instability, and adaptive responses to surgery. However, intrinsic differences among different species make translation to human shoulder pathologies difficult. Most of the animals used in experimental settings are quadrupeds, using the forelimbs for weight-bearing during locomotion, with no or minimal overhead activity. The various animal models already used to study shoulder pathologies are presented in this article. However, there is a lack of validation for these animal models, which provides challenge to the further research in this field.

Animal models for translational research on shoulder pathologies: from bench to bedside / Longo, Ug; Forriol, F; Campi, S; Maffulli, Nicola; Denaro, V.. - In: SPORTS MEDICINE AND ARTHROSCOPY REVIEW. - ISSN 1062-8592. - (2011), pp. 184-193.

Animal models for translational research on shoulder pathologies: from bench to bedside

MAFFULLI, Nicola;
2011

Abstract

Several animal models have been used for in vivo and in vitro shoulder research. In vitro models, consisting of cadaveric specimens, are useful in providing basic understanding of the functioning of the shoulder and for biomechanical experiments. In vivo models provide the means to model living phenomena, such as tendon healing process, tendinopathy, instability, and adaptive responses to surgery. However, intrinsic differences among different species make translation to human shoulder pathologies difficult. Most of the animals used in experimental settings are quadrupeds, using the forelimbs for weight-bearing during locomotion, with no or minimal overhead activity. The various animal models already used to study shoulder pathologies are presented in this article. However, there is a lack of validation for these animal models, which provides challenge to the further research in this field.
2011
01 Pubblicazione su rivista::01a Articolo in rivista
Animal models for translational research on shoulder pathologies: from bench to bedside / Longo, Ug; Forriol, F; Campi, S; Maffulli, Nicola; Denaro, V.. - In: SPORTS MEDICINE AND ARTHROSCOPY REVIEW. - ISSN 1062-8592. - (2011), pp. 184-193.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1695217
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 61
  • ???jsp.display-item.citation.isi??? 41
social impact