Adherence to vaccination recommendations is a challenge for national immunization programs. We quantified adherence to COVID-19 vaccination recommendations in people with substance use disorders (SUDs) attending an outpatient addiction center in Rome, Italy; we investigated the determinants of adherence, and also analyzed patient risk perception and compliance with preventive measures. A multivariable logistic regression model identified predictors of adherence to vaccination recommendations, with statistical validity tested by estimating adjusted odds ratios (aORs) and 95% confidence intervals (CIs). From December 2021 to January 2022, 200 SUD patients completed a questionnaire, 80% of whom reported being vaccinated against SARS-CoV-2 (minimum one dose). Negative predictors of vaccine uptake included being non-Italian (aOR: 0.36, 95% CI: 0.13-0.97), having coexisting comorbidities (aOR: 0.35, 95% CI: 0.13-0.95), and previous use of heroin (aOR: 0.24, 95% CI: 0.08-0.71). No difference was found for cocaine use, demographic characteristics, previous COVID-19 infection, methadone therapy, or compliance with preventive measures. Major reasons for non-adherence to vaccination recommendations were fear of side effects, insufficient recognition of the importance of vaccination, bureaucratic issues, and lack of trust in the authorities. Given their vulnerability, additional efforts are needed to facilitate access to vaccination for people with SUDs, and to limit disinformation around vaccines..

Adherence to SARS-CoV-2 vaccination recommendations among patients with substance use disorders. A cross-sectional study in Rome, Italy / Mondera, Francesco; Cammalleri, Vincenzo; Forestiero, Francesca Maria; Turatto, Federica; Direnzo, Giovanni F M; Napoli, Anna; Pirelli, Francesca; Razafimpanana, Nirinalisera; Rossi, Ettore; Baccolini, Valentina; Cinti, Lilia; Marzuillo, Carolina; Barra, Massimo; Antonelli, Guido; Badiani, Aldo; Villari, Paolo. - In: VACCINES. - ISSN 2076-393X. - 11:9(2023), pp. 1-11. [10.3390/vaccines11091434]

Adherence to SARS-CoV-2 vaccination recommendations among patients with substance use disorders. A cross-sectional study in Rome, Italy

Mondera, Francesco
;
Cammalleri, Vincenzo;Forestiero, Francesca Maria;Turatto, Federica;Napoli, Anna;Pirelli, Francesca;Razafimpanana, Nirinalisera;Baccolini, Valentina;Cinti, Lilia;Marzuillo, Carolina;Antonelli, Guido;Badiani, Aldo;Villari, Paolo
2023

Abstract

Adherence to vaccination recommendations is a challenge for national immunization programs. We quantified adherence to COVID-19 vaccination recommendations in people with substance use disorders (SUDs) attending an outpatient addiction center in Rome, Italy; we investigated the determinants of adherence, and also analyzed patient risk perception and compliance with preventive measures. A multivariable logistic regression model identified predictors of adherence to vaccination recommendations, with statistical validity tested by estimating adjusted odds ratios (aORs) and 95% confidence intervals (CIs). From December 2021 to January 2022, 200 SUD patients completed a questionnaire, 80% of whom reported being vaccinated against SARS-CoV-2 (minimum one dose). Negative predictors of vaccine uptake included being non-Italian (aOR: 0.36, 95% CI: 0.13-0.97), having coexisting comorbidities (aOR: 0.35, 95% CI: 0.13-0.95), and previous use of heroin (aOR: 0.24, 95% CI: 0.08-0.71). No difference was found for cocaine use, demographic characteristics, previous COVID-19 infection, methadone therapy, or compliance with preventive measures. Major reasons for non-adherence to vaccination recommendations were fear of side effects, insufficient recognition of the importance of vaccination, bureaucratic issues, and lack of trust in the authorities. Given their vulnerability, additional efforts are needed to facilitate access to vaccination for people with SUDs, and to limit disinformation around vaccines..
2023
covid-19; health disparities; substance use disorders; vaccination coverage; vaccine hesitancy; vaccines
01 Pubblicazione su rivista::01a Articolo in rivista
Adherence to SARS-CoV-2 vaccination recommendations among patients with substance use disorders. A cross-sectional study in Rome, Italy / Mondera, Francesco; Cammalleri, Vincenzo; Forestiero, Francesca Maria; Turatto, Federica; Direnzo, Giovanni F M; Napoli, Anna; Pirelli, Francesca; Razafimpanana, Nirinalisera; Rossi, Ettore; Baccolini, Valentina; Cinti, Lilia; Marzuillo, Carolina; Barra, Massimo; Antonelli, Guido; Badiani, Aldo; Villari, Paolo. - In: VACCINES. - ISSN 2076-393X. - 11:9(2023), pp. 1-11. [10.3390/vaccines11091434]
File allegati a questo prodotto
File Dimensione Formato  
Mondera_Adherence_2023 .pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 260.97 kB
Formato Adobe PDF
260.97 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1693771
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact