: We investigated 23 hepatitis C virus (HCV)-infected patients with overt lymphoproliferative diseases (15 cases) or monoclonal B lymphocytosis (8 cases) treated with direct agent antiviral (DAAs) per clinical practice. DAA therapy yielded undetectable HCV-RNA, the complete response of cryoglobulinemia vasculitis and related signs, whilst the presence of B-cell clones (evaluated by flow cytometry, IGHV, and BCL2-IGH rearrangements), detected in 19/23 cases at baseline, was maintained (17/19). Similarly, IGHV intraclonal diversification, supporting an antigen-driven selection mechanism, was identified in B-cell clones at baseline and end of follow-up. DAA therapy alone, despite HCV eradication and good immunological responses, was less effective on the pathological B-cell clones.

Persistence of monoclonal B-cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus-associated lymphoproliferative disorders / Mazzaro, Cesare; Visentini, Marcella; Gragnani, Laura; Vit, Filippo; Tissino, Erika; Pozzo, Federico; Papotti, Robel; Casato, Milvia; Zignego, Anna Linda; Bittolo, Tamara; Zucchetto, Antonella; Degan, Massimo; Bomben, Riccardo; Gattei, Valter. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 1365-2141. - 203:2(2023), pp. 237-243. [10.1111/bjh.19002]

Persistence of monoclonal B-cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus-associated lymphoproliferative disorders

Visentini, Marcella;Casato, Milvia;
2023

Abstract

: We investigated 23 hepatitis C virus (HCV)-infected patients with overt lymphoproliferative diseases (15 cases) or monoclonal B lymphocytosis (8 cases) treated with direct agent antiviral (DAAs) per clinical practice. DAA therapy yielded undetectable HCV-RNA, the complete response of cryoglobulinemia vasculitis and related signs, whilst the presence of B-cell clones (evaluated by flow cytometry, IGHV, and BCL2-IGH rearrangements), detected in 19/23 cases at baseline, was maintained (17/19). Similarly, IGHV intraclonal diversification, supporting an antigen-driven selection mechanism, was identified in B-cell clones at baseline and end of follow-up. DAA therapy alone, despite HCV eradication and good immunological responses, was less effective on the pathological B-cell clones.
2023
B-cell monoclonality; HCV; lymphoproliferative disorders; new direct antiviral agents
01 Pubblicazione su rivista::01a Articolo in rivista
Persistence of monoclonal B-cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus-associated lymphoproliferative disorders / Mazzaro, Cesare; Visentini, Marcella; Gragnani, Laura; Vit, Filippo; Tissino, Erika; Pozzo, Federico; Papotti, Robel; Casato, Milvia; Zignego, Anna Linda; Bittolo, Tamara; Zucchetto, Antonella; Degan, Massimo; Bomben, Riccardo; Gattei, Valter. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 1365-2141. - 203:2(2023), pp. 237-243. [10.1111/bjh.19002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1693020
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