: Cytokine release syndrome (CRS) following haploidentical hematopoietic cell transplantation (HCT) resembles CRS after chimeric antigen receptor-T therapy. We conducted this single-center retrospective study to evaluate the association of posthaploidentical HCT CRS with clinical outcomes and immune reconstitution. One hundred sixty-nine patients who underwent haploidentical HCT between 2011 and 2020 were identified. Of these, 98 patients (58%) developed CRS after HCT. CRS was diagnosed based on the presence of fever within the first 5 days after HCT without evidence of infection or infusion reaction and was graded according to established criteria. The development of posthaploidentical HCT CRS was associated with a lower incidence of disease relapse (P = .024) but with an increased risk of chronic graft-versus-host disease GVHD (P = .01). The association of CRS with a lower incidence of relapse was not confounded by graft source or disease diagnosis. Neither CD34 nor total nucleated cell dose was associated with CRS independently of graft type. In patients developing CRS, CD4+ Treg (P < .0005), CD4+ Tcon (P < .005), and CD8+ T cells (P < .005) increased 1 month after HCT compared with those who did not develop CRS, but not at later time points. The increase in CD4+ regulatory T cells 1 month after HCT was most notable among patients with CRS who received a bone marrow graft (P < .005). The development of posthaploidentical HCT CRS is associated with a reduced incidence of disease relapse and a transient effect on post-HCT immune reconstitution of T cells and their subsets. Therefore, the validation of these observations in a multicenter cohort is required.

Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse / Shapiro, Roman M; Kim, Haesook T; Ansuinelli, Michela; Guleria, Indira; Cutler, Corey S; Koreth, John; Gooptu, Mahasweta; Antin, Joseph H; Kelkar, Amar; Ritz, Jerome; Wu, Catherine J; Soiffer, Robert J; Ho, Vincent T; Nikiforow, Sarah; Romee, Rizwan. - In: BLOOD ADVANCES. - ISSN 2473-9537. - 7:15(2023), pp. 4080-4088. [10.1182/bloodadvances.2023009657]

Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse

Ansuinelli, Michela;
2023

Abstract

: Cytokine release syndrome (CRS) following haploidentical hematopoietic cell transplantation (HCT) resembles CRS after chimeric antigen receptor-T therapy. We conducted this single-center retrospective study to evaluate the association of posthaploidentical HCT CRS with clinical outcomes and immune reconstitution. One hundred sixty-nine patients who underwent haploidentical HCT between 2011 and 2020 were identified. Of these, 98 patients (58%) developed CRS after HCT. CRS was diagnosed based on the presence of fever within the first 5 days after HCT without evidence of infection or infusion reaction and was graded according to established criteria. The development of posthaploidentical HCT CRS was associated with a lower incidence of disease relapse (P = .024) but with an increased risk of chronic graft-versus-host disease GVHD (P = .01). The association of CRS with a lower incidence of relapse was not confounded by graft source or disease diagnosis. Neither CD34 nor total nucleated cell dose was associated with CRS independently of graft type. In patients developing CRS, CD4+ Treg (P < .0005), CD4+ Tcon (P < .005), and CD8+ T cells (P < .005) increased 1 month after HCT compared with those who did not develop CRS, but not at later time points. The increase in CD4+ regulatory T cells 1 month after HCT was most notable among patients with CRS who received a bone marrow graft (P < .005). The development of posthaploidentical HCT CRS is associated with a reduced incidence of disease relapse and a transient effect on post-HCT immune reconstitution of T cells and their subsets. Therefore, the validation of these observations in a multicenter cohort is required.
2023
CD34 antigen; CD4 antigen; CD8 antigen; cyclophosphamide; mycophenolate mofetil; sirolimus; tacrolimus; tocilizumab
01 Pubblicazione su rivista::01a Articolo in rivista
Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse / Shapiro, Roman M; Kim, Haesook T; Ansuinelli, Michela; Guleria, Indira; Cutler, Corey S; Koreth, John; Gooptu, Mahasweta; Antin, Joseph H; Kelkar, Amar; Ritz, Jerome; Wu, Catherine J; Soiffer, Robert J; Ho, Vincent T; Nikiforow, Sarah; Romee, Rizwan. - In: BLOOD ADVANCES. - ISSN 2473-9537. - 7:15(2023), pp. 4080-4088. [10.1182/bloodadvances.2023009657]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1692966
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact