The sleep–wake cycle is a complex multifactorial process involving several neurotransmitters, including acetylcholine, norepinephrine, serotonin, histamine, dopamine, orexin and GABA, that can be, in turn, regulated by different nutrients involved in their metabolic pathways. Although good sleep quality in children has been proven to be a key factor for optimal cognitive, physical and psychological development, a significant and ever-increasing percentage of the pediatric population suffers from sleep disorders. In children, behavioral interventions along with supplements are recommended as the first line treatment. This systematic review was conducted, according to the PRISMA guidelines, with the purpose of assessing the principal nutrients involved in the pathways of sleep-regulating neurotransmitters in children and adolescents. Our focus was the utilization of over the counter (OTC) products, specifically iron, hydroxytryptophan, theanine and antihistamines in the management of different pediatric sleep disorders with the intention of providing a practical guide for the clinician.

The Role of Supplements and Over-the-Counter Products to Improve Sleep in Children: A Systematic Review / Innocenti, Alice; Lentini, Giuliana; Rapacchietta, Serena; Cinnirella, Paola; Elia, Maurizio; Ferri, Raffaele; Bruni, Oliviero. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - (2023). [10.3390/ijms24097821]

The Role of Supplements and Over-the-Counter Products to Improve Sleep in Children: A Systematic Review

Alice Innocenti;Giuliana Lentini;Serena Rapacchietta;Paola Cinnirella;Oliviero Bruni
Ultimo
2023

Abstract

The sleep–wake cycle is a complex multifactorial process involving several neurotransmitters, including acetylcholine, norepinephrine, serotonin, histamine, dopamine, orexin and GABA, that can be, in turn, regulated by different nutrients involved in their metabolic pathways. Although good sleep quality in children has been proven to be a key factor for optimal cognitive, physical and psychological development, a significant and ever-increasing percentage of the pediatric population suffers from sleep disorders. In children, behavioral interventions along with supplements are recommended as the first line treatment. This systematic review was conducted, according to the PRISMA guidelines, with the purpose of assessing the principal nutrients involved in the pathways of sleep-regulating neurotransmitters in children and adolescents. Our focus was the utilization of over the counter (OTC) products, specifically iron, hydroxytryptophan, theanine and antihistamines in the management of different pediatric sleep disorders with the intention of providing a practical guide for the clinician.
2023
pediatric sleep disorder; treatment; tryptophan; iron; antihistamines; theanine; insomnia; awakenings
01 Pubblicazione su rivista::01a Articolo in rivista
The Role of Supplements and Over-the-Counter Products to Improve Sleep in Children: A Systematic Review / Innocenti, Alice; Lentini, Giuliana; Rapacchietta, Serena; Cinnirella, Paola; Elia, Maurizio; Ferri, Raffaele; Bruni, Oliviero. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - (2023). [10.3390/ijms24097821]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1692899
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 0
social impact