Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous system (CNS). They influence neuronal functions and circuit activities with effects on memory processes and behaviors. Here, we unravel a neuromodulatory activity of interleukin-15 (IL-15) in mouse brain. Acute exposure of hippocampal slices to IL-15 enhances gamma-aminobutyricacid (GABA) release and reduces glutamatergic currents, while chronic treatment with IL-15 increases the frequency of hippocampal miniature inhibitory synaptic transmission and impairs memory formation in the novel object recognition (NOR) test. Moreover, we describe that serotonin is involved in mediating the hippocampal effects of IL-15, because a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and ameliorates mice performance in the NOR test. These findings provide new insights into the modulatory activities of cytokines in the CNS, with implications on behavior.

Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice / DI CASTRO, MARIA AMALIA; Garofalo, Stefano; Mormino, Alessandro; Carbonari, Laura; DI PIETRO, Erika; De Felice, Eleonora; Catalano, Myriam; Maggi, Laura; Limatola, Cristina. - In: BRAIN BEHAVIOR AND IMMUNITY. - ISSN 0889-1591. - 23:(2023), p. 1591. [10.1016/j.bbi.2023.11.015]

Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice

Maria Amalia Di Castro;Stefano Garofalo
Co-primo
Conceptualization
;
Alessandro Mormino;Laura Carbonari;Erika Di Pietro;Eleonora De Felice;Myriam Catalano;Laura Maggi;Cristina Limatola
2023

Abstract

Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous system (CNS). They influence neuronal functions and circuit activities with effects on memory processes and behaviors. Here, we unravel a neuromodulatory activity of interleukin-15 (IL-15) in mouse brain. Acute exposure of hippocampal slices to IL-15 enhances gamma-aminobutyricacid (GABA) release and reduces glutamatergic currents, while chronic treatment with IL-15 increases the frequency of hippocampal miniature inhibitory synaptic transmission and impairs memory formation in the novel object recognition (NOR) test. Moreover, we describe that serotonin is involved in mediating the hippocampal effects of IL-15, because a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and ameliorates mice performance in the NOR test. These findings provide new insights into the modulatory activities of cytokines in the CNS, with implications on behavior.
2023
cytokines; neuromodulation; mice; behavior
01 Pubblicazione su rivista::01a Articolo in rivista
Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice / DI CASTRO, MARIA AMALIA; Garofalo, Stefano; Mormino, Alessandro; Carbonari, Laura; DI PIETRO, Erika; De Felice, Eleonora; Catalano, Myriam; Maggi, Laura; Limatola, Cristina. - In: BRAIN BEHAVIOR AND IMMUNITY. - ISSN 0889-1591. - 23:(2023), p. 1591. [10.1016/j.bbi.2023.11.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1692292
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