Abstract Background The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications, mortality, less-than-radical oncologic surgery, and indications for neoadjuvant therapy. Methods Retrospective analysis of 16,883 colorectal cancer cases from 80 centres (2018–2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal of ≥ 12 lymph nodes; non-radical resection; neoadjuvant therapy. Quartiles of hospital volumes were classified as LOW, MEDIUM, HIGH, and VERY HIGH. Independent predictors, both overall and for rectal cancer, were evaluated using logistic regression including age, gender, AJCC stage and cancer site. Results LOW-volume centres reported a higher rate of severe postoperative complications (OR 1.50, 95% c.i. 1.15–1.096, P = 0.003). The rate of ≥ 12 lymph nodes removed in LOW-volume (OR 0.68, 95% c.i. 0.56–0.85, P < 0.001) and MEDIUM-volume (OR 0.72, 95% c.i. 0.62–0.83, P < 0.001) centres was lower than in VERY HIGH-volume centres. Of the 4676 rectal cancer patients, the rate of ≥ 12 lymph nodes removed was lower in LOW-volume than in VERY HIGH-volume centres (OR 0.57, 95% c.i. 0.41–0.80, P = 0.001). A lower rate of neoadjuvant chemoradiation was associated with HIGH (OR 0.66, 95% c.i. 0.56–0.77, P < 0.001), MEDIUM (OR 0.75, 95% c.i. 0.60–0.92, P = 0.006), and LOW (OR 0.70, 95% c.i. 0.52–0.94, P = 0.019) volume centres (vs. VERY HIGH). Conclusion Colorectal cancer surgery in low-volume centres is at higher risk of suboptimal management, poor postoperative outcomes, and less-than-adequate oncologic resections. Centralisation of rectal cancer cases should be taken into consideration to optimise the outcomes.

Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer. Results of a multicentre national study / Rottoli, Matteo; Spinelli, Antonino; Pellino, Gianluca; Gori, Alice; Calini, Giacomo; E Flacco, Maria; Manzoli, Lamberto; Poggioli, Gilberto; Lapolla, Pierfrancesco; Mingoli, Andrea; Sapienza, Paolo; Brachini, Gioia; Cirillo, Bruno; Fiori, Enrico; Crocetti, Daniele; Clementi, Ilaria. - In: BRITISH JOURNAL OF SURGERY. - ISSN 1365-2168. - 111:1(2023), pp. 1-9. [10.1093/bjs/znad373]

Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer. Results of a multicentre national study

Lamberto Manzoli;Pierfrancesco Lapolla;Andrea Mingoli;Paolo Sapienza;Gioia Brachini;Bruno Cirillo;Enrico Fiori;Daniele Crocetti;Ilaria Clementi
2023

Abstract

Abstract Background The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications, mortality, less-than-radical oncologic surgery, and indications for neoadjuvant therapy. Methods Retrospective analysis of 16,883 colorectal cancer cases from 80 centres (2018–2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal of ≥ 12 lymph nodes; non-radical resection; neoadjuvant therapy. Quartiles of hospital volumes were classified as LOW, MEDIUM, HIGH, and VERY HIGH. Independent predictors, both overall and for rectal cancer, were evaluated using logistic regression including age, gender, AJCC stage and cancer site. Results LOW-volume centres reported a higher rate of severe postoperative complications (OR 1.50, 95% c.i. 1.15–1.096, P = 0.003). The rate of ≥ 12 lymph nodes removed in LOW-volume (OR 0.68, 95% c.i. 0.56–0.85, P < 0.001) and MEDIUM-volume (OR 0.72, 95% c.i. 0.62–0.83, P < 0.001) centres was lower than in VERY HIGH-volume centres. Of the 4676 rectal cancer patients, the rate of ≥ 12 lymph nodes removed was lower in LOW-volume than in VERY HIGH-volume centres (OR 0.57, 95% c.i. 0.41–0.80, P = 0.001). A lower rate of neoadjuvant chemoradiation was associated with HIGH (OR 0.66, 95% c.i. 0.56–0.77, P < 0.001), MEDIUM (OR 0.75, 95% c.i. 0.60–0.92, P = 0.006), and LOW (OR 0.70, 95% c.i. 0.52–0.94, P = 0.019) volume centres (vs. VERY HIGH). Conclusion Colorectal cancer surgery in low-volume centres is at higher risk of suboptimal management, poor postoperative outcomes, and less-than-adequate oncologic resections. Centralisation of rectal cancer cases should be taken into consideration to optimise the outcomes.
2023
gastrointestinal surgery; pathological outcomes; multicentre national study
01 Pubblicazione su rivista::01a Articolo in rivista
Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer. Results of a multicentre national study / Rottoli, Matteo; Spinelli, Antonino; Pellino, Gianluca; Gori, Alice; Calini, Giacomo; E Flacco, Maria; Manzoli, Lamberto; Poggioli, Gilberto; Lapolla, Pierfrancesco; Mingoli, Andrea; Sapienza, Paolo; Brachini, Gioia; Cirillo, Bruno; Fiori, Enrico; Crocetti, Daniele; Clementi, Ilaria. - In: BRITISH JOURNAL OF SURGERY. - ISSN 1365-2168. - 111:1(2023), pp. 1-9. [10.1093/bjs/znad373]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1692248
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