α-Synuclein (αS) is of wide interest because its aggregation is a hallmark of many neurodegenerative disorders, including Parkinson’s disease. Here, we are using the atomic force microscopy-assisted infrared nanospectroscopy to investigate its aggregation into nanoscale fibrils and describe the secondary structure change of the protein during aggregation. Perspective THz irradiation experiments have been designed and are being set up, with the aim of modifying the secondary structure of proteins and/or aggregates through prolonged THz irradiation with CW sources.
Infrared Nanospectroscopy and Terahertz Irradiation of Pathological Protein Aggregates / Intze, A.; Polito, R.; Temperini, M. E.; Giliberti, V.; Ortolani, M.. - (2023), pp. 1-2. (Intervento presentato al convegno 2023 48th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz) tenutosi a Montreal, QC, Canada) [10.1109/IRMMW-THz57677.2023.10299259].
Infrared Nanospectroscopy and Terahertz Irradiation of Pathological Protein Aggregates
Intze, A.;Polito, R.;Temperini, M. E.;Giliberti, V.;
2023
Abstract
α-Synuclein (αS) is of wide interest because its aggregation is a hallmark of many neurodegenerative disorders, including Parkinson’s disease. Here, we are using the atomic force microscopy-assisted infrared nanospectroscopy to investigate its aggregation into nanoscale fibrils and describe the secondary structure change of the protein during aggregation. Perspective THz irradiation experiments have been designed and are being set up, with the aim of modifying the secondary structure of proteins and/or aggregates through prolonged THz irradiation with CW sources.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
