SUMMARY: Serum assays for PCA, IFA, gastrin, and pepsinogen I show good diagnostic accuracy for noninvasive diagnostic work-up of AAG. Diagnostic performance may increase by combining >1 of these tests, overcoming the problem of seronegative AAG. However, appropriately designed, comparative studies with well-characterized patient cohorts are needed to better define the reliability of these biomarkers in the diagnosis of patients with AAG. Currently, positive serum tests should always be followed by the state-of-art diagnostic test, that is, histopathological assessment of gastric biopsies obtained during gastroscopy to definitively confirm or rule out AAG and eventually neoplastic complications.

Update on Serum Biomarkers in Autoimmune Atrophic Gastritis / Dottori, Ludovica; Pivetta, Giulia; Annibale, Bruno; Lahner, Edith. - In: CLINICAL CHEMISTRY. - ISSN 1530-8561. - 69:10(2023), pp. 1114-1131. [10.1093/clinchem/hvad082]

Update on Serum Biomarkers in Autoimmune Atrophic Gastritis

Dottori Ludovica;Giulia Pivetta;Bruno Annibale;Edith Lahner
2023

Abstract

SUMMARY: Serum assays for PCA, IFA, gastrin, and pepsinogen I show good diagnostic accuracy for noninvasive diagnostic work-up of AAG. Diagnostic performance may increase by combining >1 of these tests, overcoming the problem of seronegative AAG. However, appropriately designed, comparative studies with well-characterized patient cohorts are needed to better define the reliability of these biomarkers in the diagnosis of patients with AAG. Currently, positive serum tests should always be followed by the state-of-art diagnostic test, that is, histopathological assessment of gastric biopsies obtained during gastroscopy to definitively confirm or rule out AAG and eventually neoplastic complications.
2023
autoimmune atrophic gastritis; gastrin; pepsinogen; parietal cell antibodies; intrinisic factor antibodies
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Update on Serum Biomarkers in Autoimmune Atrophic Gastritis / Dottori, Ludovica; Pivetta, Giulia; Annibale, Bruno; Lahner, Edith. - In: CLINICAL CHEMISTRY. - ISSN 1530-8561. - 69:10(2023), pp. 1114-1131. [10.1093/clinchem/hvad082]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1690697
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