Prognostic role of chromosomal translocations (CT) in myelodysplasia (MDS) was retrospectively analyzed in 77 patients from GROM-L registry. Forty (51.9\%) balanced, 28 (36.4\%) unbalanced and 9 (11.7\%) concomitant balanced and unbalanced CT were identified. Five-year overall survival (OS) of the entire cohort was 34.5\% (CI 95\% 22.5-46.5). Five-year OS of patients with unbalanced CT was significantly shorter than that of patients carrying balanced CT {[}22.3\% (CI 95\% 4.0-40.6) vs 44.0\% (CI 95\% 26.7-61.3) (p = 0.042)]. Five-year OS of patients with CT included in complex karyotype (CK) was significantly shorter than that of patients with isolated CT or CT with another abnormality {[}5.5\% (CI 95\% 0-15.7) vs 42.9\% (CI 95\% 21.3-64.5) and vs 4\% (CI 95\% 31.6-79.2) (p < 0.001)]. Presence of CT in MDS characterizes a more aggressive outcome only when associated with CK.
Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance / Mohamed, Sara; Latagliata, Roberto; Limongi, Maria Zaira; Nigro, Stefania; Sangiorgi, Eleonora; Nanni, Mauro; Piccioni, Annalina; Campagna, Alessia; Spiriti, Maria Antonietta Aloe; Carmosino, Ida; Molica, Matteo; Mariggio, Elena; Rosati, Serena; Colafigli, Gioia; Fazio, Francesca; De Luca, Maria Lucia; De Benedittis, Daniela; Scalzulli, Emilia; Breccia, Massimo; Mancini, Marco. - In: LEUKEMIA & LYMPHOMA. - ISSN 1042-8194. - 61:14(2020), pp. 3476-3483. [10.1080/10428194.2020.1811861]
Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance
Mohamed, Sara;Limongi, Maria Zaira;Nigro, Stefania;Spiriti, Maria Antonietta Aloe;Carmosino, Ida;Colafigli, Gioia;Fazio, Francesca;De Luca, Maria Lucia;Scalzulli, Emilia;Breccia, Massimo;Mancini, Marco
2020
Abstract
Prognostic role of chromosomal translocations (CT) in myelodysplasia (MDS) was retrospectively analyzed in 77 patients from GROM-L registry. Forty (51.9\%) balanced, 28 (36.4\%) unbalanced and 9 (11.7\%) concomitant balanced and unbalanced CT were identified. Five-year overall survival (OS) of the entire cohort was 34.5\% (CI 95\% 22.5-46.5). Five-year OS of patients with unbalanced CT was significantly shorter than that of patients carrying balanced CT {[}22.3\% (CI 95\% 4.0-40.6) vs 44.0\% (CI 95\% 26.7-61.3) (p = 0.042)]. Five-year OS of patients with CT included in complex karyotype (CK) was significantly shorter than that of patients with isolated CT or CT with another abnormality {[}5.5\% (CI 95\% 0-15.7) vs 42.9\% (CI 95\% 21.3-64.5) and vs 4\% (CI 95\% 31.6-79.2) (p < 0.001)]. Presence of CT in MDS characterizes a more aggressive outcome only when associated with CK.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
