IntroductionLiver fibrosis is a risk factor for liver-related adverse outcomes and cardiovascular disease (CVD). Recently, the non-invasive Hepamet fibrosis score (HFS) has been validated as a tool capable to identify with good diagnostic accuracy subjects with advanced liver fibrosis. It is unsettled whether HFS is capable to identify individuals at higher risk of CVD. To investigate whether individuals with liver fibrosis measured with HFS have higher risk of myocardial infarction (MI) in adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study.MethodsParticipants (n = 2948) were divided into three groups according to HFS: low risk of fibrosis (<0.12); intermediate risk of fibrosis (=0.12 to <0.47); high risk of fibrosis (=0.47). The association between the liver fibrosis risk and MI was analysed by a logistic regression analysis.ResultsAs compared with those having the lowest risk (5.3%), a higher proportion of subjects with moderate or high risk of liver fibrosis had MI (12.9% and 24.4%, respectively; p < 0.001). In a logistic regression analysis, individuals at increased risk of liver fibrosis exhibited a threefold increased risk of having MI as compared to those with low risk (OR 3.18; 95% CI 1.31-7.70) independently of confounders including smoking, cholesterol, triglycerides, anti-hypertensive, lipid-lowering and glucose-lowering therapies.ConclusionsIn this cross-sectional study, individuals with higher values of HFS show a higher risk of MI, suggesting that HFS may be a useful tool to identify not only individuals with liver fibrosis but also those at the increased risk of CVD.

Liver fibrosis is associated with an increased risk of non-fatal myocardial infarction / Riccio, Alessia; Mazzanti, Camilla; Vero, Laura; Fiorentino, Teresa Vanessa; Succurro, Elena; Rubino, Mariangela; Massimino, Mattia; Mannino, Gaia Chiara; Sciacqua, Angela; Andreozzi, Francesco; Cefalo, Chiara Maria Assunta; Sesti, Giorgio. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0014-2972. - 53:11(2023), pp. 1-9. [10.1111/eci.14061]

Liver fibrosis is associated with an increased risk of non-fatal myocardial infarction

Riccio, Alessia
Co-primo
;
Mazzanti, Camilla
Co-primo
;
Vero, Laura
Co-primo
;
Cefalo, Chiara Maria Assunta
Penultimo
Writing – Review & Editing
;
Sesti, Giorgio
Ultimo
Writing – Review & Editing
2023

Abstract

IntroductionLiver fibrosis is a risk factor for liver-related adverse outcomes and cardiovascular disease (CVD). Recently, the non-invasive Hepamet fibrosis score (HFS) has been validated as a tool capable to identify with good diagnostic accuracy subjects with advanced liver fibrosis. It is unsettled whether HFS is capable to identify individuals at higher risk of CVD. To investigate whether individuals with liver fibrosis measured with HFS have higher risk of myocardial infarction (MI) in adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study.MethodsParticipants (n = 2948) were divided into three groups according to HFS: low risk of fibrosis (<0.12); intermediate risk of fibrosis (=0.12 to <0.47); high risk of fibrosis (=0.47). The association between the liver fibrosis risk and MI was analysed by a logistic regression analysis.ResultsAs compared with those having the lowest risk (5.3%), a higher proportion of subjects with moderate or high risk of liver fibrosis had MI (12.9% and 24.4%, respectively; p < 0.001). In a logistic regression analysis, individuals at increased risk of liver fibrosis exhibited a threefold increased risk of having MI as compared to those with low risk (OR 3.18; 95% CI 1.31-7.70) independently of confounders including smoking, cholesterol, triglycerides, anti-hypertensive, lipid-lowering and glucose-lowering therapies.ConclusionsIn this cross-sectional study, individuals with higher values of HFS show a higher risk of MI, suggesting that HFS may be a useful tool to identify not only individuals with liver fibrosis but also those at the increased risk of CVD.
2023
Hepamet fibrosis score; NAFLD; cardiovascular disease; hepatic fibrosis
01 Pubblicazione su rivista::01a Articolo in rivista
Liver fibrosis is associated with an increased risk of non-fatal myocardial infarction / Riccio, Alessia; Mazzanti, Camilla; Vero, Laura; Fiorentino, Teresa Vanessa; Succurro, Elena; Rubino, Mariangela; Massimino, Mattia; Mannino, Gaia Chiara; Sciacqua, Angela; Andreozzi, Francesco; Cefalo, Chiara Maria Assunta; Sesti, Giorgio. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0014-2972. - 53:11(2023), pp. 1-9. [10.1111/eci.14061]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1690346
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