The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. The disease entities discussed include primary effusion lymphomas (PEL), extracavitary primary effusion lymphomas and confounding entities (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, and plasmablastic types), diffuse large B-cell lymphoma associated with chronic inflammation, fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), and other lymphomas presenting as an effusion. All entities above are discussed; however, three are delved into greater detail given the challenges with classification: ECPEL, HHV8-negative effusion-based lymphomas, and FA-DLBCL. Cases exemplifying the diagnostic difficulty in differentiating ECPEL from HHV8-positive diffuse large B-cell lymphoma and germinotropic lymphoproliferative disorder were discussed. The more recently recognized effusion-based HHV8-negative large B-cell lymphoma is explored, with several cases submitted raising the question if this subset should be carved out as a specific entity, and if so, what should be the refining diagnostic criteria. Case submissions to the FA-DLBCL section yielded one of the largest case series to date, including classic cases, cases furthering the discussion on disease sites and prognosis, as well as novel concepts to be considered in this entity. The 2022 EA4HP/SH workshop cases allowed for further confirmation of the characteristics of some of the more historically accepted cavity-based lymphomas, as well as further inquiry and debate on relatively new or evolving entities.

Cavity-based lymphomas. challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop / Di Napoli, Arianna; Soma, Lori; Quintanilla-Martinez, Leticia; de Leval, Laurence; Leoncini, Lorenzo; Zamò, Alberto; Ng, Siok-Bian; Ondrejka, Sarah L; Climent, Fina; Wotherspoon, Andrew; Dirnhofer, Stefan. - In: VIRCHOWS ARCHIV. - ISSN 1432-2307. - 483:3(2023), pp. 299-316. [10.1007/s00428-023-03599-2]

Cavity-based lymphomas. challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop

Di Napoli, Arianna
;
2023

Abstract

The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. The disease entities discussed include primary effusion lymphomas (PEL), extracavitary primary effusion lymphomas and confounding entities (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, and plasmablastic types), diffuse large B-cell lymphoma associated with chronic inflammation, fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), and other lymphomas presenting as an effusion. All entities above are discussed; however, three are delved into greater detail given the challenges with classification: ECPEL, HHV8-negative effusion-based lymphomas, and FA-DLBCL. Cases exemplifying the diagnostic difficulty in differentiating ECPEL from HHV8-positive diffuse large B-cell lymphoma and germinotropic lymphoproliferative disorder were discussed. The more recently recognized effusion-based HHV8-negative large B-cell lymphoma is explored, with several cases submitted raising the question if this subset should be carved out as a specific entity, and if so, what should be the refining diagnostic criteria. Case submissions to the FA-DLBCL section yielded one of the largest case series to date, including classic cases, cases furthering the discussion on disease sites and prognosis, as well as novel concepts to be considered in this entity. The 2022 EA4HP/SH workshop cases allowed for further confirmation of the characteristics of some of the more historically accepted cavity-based lymphomas, as well as further inquiry and debate on relatively new or evolving entities.
2023
breast implant associated anaplastic large cell lymphoma; effusion-based large b cell lymphoma; extracavitary primary effusion lymphoma; fibrin-associated large b cell lymphoma; fluid overload associated large b cell lymphoma; germinotropic disorder; HHV8-negative effusion lymphoma; Pleural Effusion Lymphoma
01 Pubblicazione su rivista::01a Articolo in rivista
Cavity-based lymphomas. challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop / Di Napoli, Arianna; Soma, Lori; Quintanilla-Martinez, Leticia; de Leval, Laurence; Leoncini, Lorenzo; Zamò, Alberto; Ng, Siok-Bian; Ondrejka, Sarah L; Climent, Fina; Wotherspoon, Andrew; Dirnhofer, Stefan. - In: VIRCHOWS ARCHIV. - ISSN 1432-2307. - 483:3(2023), pp. 299-316. [10.1007/s00428-023-03599-2]
File allegati a questo prodotto
File Dimensione Formato  
DiNapoli_A-cavity-lymphomas_2023.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 4.15 MB
Formato Adobe PDF
4.15 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1690299
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
social impact