Familial adenomatous polyposis is an autosomal dominant disease due to a mutation in the adenomatous polyposis coli (APC) gene. The disease, characterized by the development of adenomas throughout the colon and rectum, is also associated with extracolonic manifestations including gastric fundic polyps and cancer. In this report, we describe two patients with FAP with advanced gastric adenocarcinoma who received systemic chemotherapy. We reviewed the literature published over the past two decades on gastric cancer in FAP patients to assess the clinical course of this disease. Due to its recent increased incidence in Western countries, close endoscopic surveillance to detect early gastric neoplastic lesions is recommended.

Two Cases, Too Little, Too Late: Surveillance for Gastric Cancer in Patients with FAP / Varanese, Marzia; Lattina, Ilario; Frattaroli, Flaminia; Assisi, Daniela; Sanchez-Mete, Lupe; Baldissone, Elena; Lauro, Augusto; Stigliano, Vittoria. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - (2023). [10.1007/s10620-023-08097-8]

Two Cases, Too Little, Too Late: Surveillance for Gastric Cancer in Patients with FAP

Varanese, Marzia;Lattina, Ilario
;
Frattaroli, Flaminia;Lauro, Augusto
Penultimo
Writing – Review & Editing
;
2023

Abstract

Familial adenomatous polyposis is an autosomal dominant disease due to a mutation in the adenomatous polyposis coli (APC) gene. The disease, characterized by the development of adenomas throughout the colon and rectum, is also associated with extracolonic manifestations including gastric fundic polyps and cancer. In this report, we describe two patients with FAP with advanced gastric adenocarcinoma who received systemic chemotherapy. We reviewed the literature published over the past two decades on gastric cancer in FAP patients to assess the clinical course of this disease. Due to its recent increased incidence in Western countries, close endoscopic surveillance to detect early gastric neoplastic lesions is recommended.
2023
endoscopic surveillance; familial adenomatous polyposis; gastric cancer
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Two Cases, Too Little, Too Late: Surveillance for Gastric Cancer in Patients with FAP / Varanese, Marzia; Lattina, Ilario; Frattaroli, Flaminia; Assisi, Daniela; Sanchez-Mete, Lupe; Baldissone, Elena; Lauro, Augusto; Stigliano, Vittoria. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - (2023). [10.1007/s10620-023-08097-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1688733
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