Cardiovascular diseases are the first cause of death worldwide, with a heavy social and economic impact. They include a wide range of pathological conditions, among which cardiac fibrosis represents a common pathogenetic hallmark. The fibrotic process is driven by cardiac mesenchymal stromal cells, namely fibroblasts, which become activated, proliferate, and differentiate into myofibroblasts in response to several stimuli, in the end secreting extracellular matrix proteins, and mediating cardiac tissue remodelling and stiffening. A specific therapy for the exclusive treatment of cardiac fibrosis is still lacking. Given the growing quest for reducing the burden of cardiovascular diseases, there is increasing interest in the search for new effective anti-fibrotic therapies. In this review, we will briefly summarize the limited pharmacological therapies known to act, at least in part, against cardiac fibrosis. Then we will present novel potential active molecules, molecular targets, and biotechnological approaches emerged in the last decade, as possible future therapeutic strategies for cardiac fibrosis, with a specific focus on targeting fibroblast activation and function.

A review of therapeutic strategies against cardiac fibrosis. From classical pharmacology to novel molecular, epigenetic, and biotechnological approaches / Floris, E.; Cozzolino, C.; Marconi, S.; Tonicello, F.; Picchio, V.; Pagano, F.; Chimenti, I.. - In: REVIEWS IN CARDIOVASCULAR MEDICINE. - ISSN 1530-6550. - 24:8(2023). [10.31083/j.rcm2408226]

A review of therapeutic strategies against cardiac fibrosis. From classical pharmacology to novel molecular, epigenetic, and biotechnological approaches

Floris E.
Primo
;
Cozzolino C.;Picchio V.;Chimenti I.
Ultimo
2023

Abstract

Cardiovascular diseases are the first cause of death worldwide, with a heavy social and economic impact. They include a wide range of pathological conditions, among which cardiac fibrosis represents a common pathogenetic hallmark. The fibrotic process is driven by cardiac mesenchymal stromal cells, namely fibroblasts, which become activated, proliferate, and differentiate into myofibroblasts in response to several stimuli, in the end secreting extracellular matrix proteins, and mediating cardiac tissue remodelling and stiffening. A specific therapy for the exclusive treatment of cardiac fibrosis is still lacking. Given the growing quest for reducing the burden of cardiovascular diseases, there is increasing interest in the search for new effective anti-fibrotic therapies. In this review, we will briefly summarize the limited pharmacological therapies known to act, at least in part, against cardiac fibrosis. Then we will present novel potential active molecules, molecular targets, and biotechnological approaches emerged in the last decade, as possible future therapeutic strategies for cardiac fibrosis, with a specific focus on targeting fibroblast activation and function.
2023
iological therapies; cardiac fibroblasts; cardiac fibrosis; cardiac remodeling; cardiac stromal cells; non-coding RNAs; precision medicine; RNA-therapeutics
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
A review of therapeutic strategies against cardiac fibrosis. From classical pharmacology to novel molecular, epigenetic, and biotechnological approaches / Floris, E.; Cozzolino, C.; Marconi, S.; Tonicello, F.; Picchio, V.; Pagano, F.; Chimenti, I.. - In: REVIEWS IN CARDIOVASCULAR MEDICINE. - ISSN 1530-6550. - 24:8(2023). [10.31083/j.rcm2408226]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1688694
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