Background and Objectives This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality. Methods Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who attended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal outcome). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin amylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period. Results ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes. Conclusion The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal outcomes.

Investigating biomarkers for COVID-19 morbidity and mortality / Ceci, Flavio Maria; Ferraguti, Giampiero; Lucarelli, Marco; Angeloni, Antonio; Bonci, Enea; Petrella, Carla; Francati, Silvia; Barbato, Christian; Di Certo, Maria Grazia; Gabanella, Francesca; Gavaruzzi, Francesca; Mastroianni, Claudio Maria; Minni, Antonio; Greco, Antonio; Ralli, Massimo; Ceccanti, Mauro; Tarani, Luigi; Fiore, Marco. - In: CURRENT TOPICS IN MEDICINAL CHEMISTRY. - ISSN 1568-0266. - 23:13(2023), pp. 1196-1210. [10.2174/1568026623666230222094517]

Investigating biomarkers for COVID-19 morbidity and mortality

Ferraguti, Giampiero
Co-primo
;
Lucarelli, Marco
Secondo
;
Angeloni, Antonio;Bonci, Enea;Petrella, Carla;Gavaruzzi, Francesca;Mastroianni, Claudio Maria;Minni, Antonio;Greco, Antonio;Ralli, Massimo;Tarani, Luigi
Penultimo
;
2023

Abstract

Background and Objectives This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality. Methods Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who attended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal outcome). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin amylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period. Results ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes. Conclusion The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal outcomes.
2023
albumin; biomarker; COVID-19; early predictor; myoglobin; SARS-CoV-2
01 Pubblicazione su rivista::01a Articolo in rivista
Investigating biomarkers for COVID-19 morbidity and mortality / Ceci, Flavio Maria; Ferraguti, Giampiero; Lucarelli, Marco; Angeloni, Antonio; Bonci, Enea; Petrella, Carla; Francati, Silvia; Barbato, Christian; Di Certo, Maria Grazia; Gabanella, Francesca; Gavaruzzi, Francesca; Mastroianni, Claudio Maria; Minni, Antonio; Greco, Antonio; Ralli, Massimo; Ceccanti, Mauro; Tarani, Luigi; Fiore, Marco. - In: CURRENT TOPICS IN MEDICINAL CHEMISTRY. - ISSN 1568-0266. - 23:13(2023), pp. 1196-1210. [10.2174/1568026623666230222094517]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1688303
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