Three seriesof metalsalophencomplexesderivedfromZn2+,Cu2+, Pt2+and Ni2+havebeensynthesizedand their interaction with quadruplex DNA has been evaluated. The compounds differ on the number of ethylpiperidinesubstituents.They have been characterized by 1H NMR, IR and UV-visible spectroscopies and by HR-masss pectrometry.Their luminescent properties have been also evaluated and we can observe that, as expected,Zn2+and Pt2+complexesare those displaying more interesting luminescence with an emission band red-shifted with respect to the corresponding uncoordinated ligand. DNAinteractionswithG4 and duplex DNA were evaluated by FRET melting assays(for the Zn2+, Cu2+and Ni2+complexes)and by emission titrations(for one Pt2+complex)which indicated that the disubstitutedcompounds2-Niand2-Ptare the only onesthat display good affinityfor G4 DNAstructures
Syntheses, characterization, and DNA binding studies of a series of copper(II), nickel(II), platinum(II) and zinc(II) complexes derived from Schiff base ligand / Iannace, V.; Sabaté, F.; Bartlett, M.; Berrones Reyes, J.; Lázaro, A.; Fantoni, A.; Vilar, R.; Rodríguez, L.; Dalla Cort, A.. - In: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. - ISSN 1099-0682. - e202300144(2023). [10.1002/ejic.202300144]
Syntheses, characterization, and DNA binding studies of a series of copper(II), nickel(II), platinum(II) and zinc(II) complexes derived from Schiff base ligand
A. FantoniMembro del Collaboration Group
;A. Dalla Cort
Ultimo
2023
Abstract
Three seriesof metalsalophencomplexesderivedfromZn2+,Cu2+, Pt2+and Ni2+havebeensynthesizedand their interaction with quadruplex DNA has been evaluated. The compounds differ on the number of ethylpiperidinesubstituents.They have been characterized by 1H NMR, IR and UV-visible spectroscopies and by HR-masss pectrometry.Their luminescent properties have been also evaluated and we can observe that, as expected,Zn2+and Pt2+complexesare those displaying more interesting luminescence with an emission band red-shifted with respect to the corresponding uncoordinated ligand. DNAinteractionswithG4 and duplex DNA were evaluated by FRET melting assays(for the Zn2+, Cu2+and Ni2+complexes)and by emission titrations(for one Pt2+complex)which indicated that the disubstitutedcompounds2-Niand2-Ptare the only onesthat display good affinityfor G4 DNAstructuresI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
