Oxidized LDL (oxLDL) and oxysterols are known to play a crucial role in endothelial dysfunction (ED) by inducing endoplasmic reticulum stress (ERS), inflammation, and apoptosis. However, the precise molecular mechanisms underlying these pathophysiological processes remain incompletely understood. Emerging evidence strongly implicates excessive nitric oxide (NO) production in the progression of various pathological conditions. The accumulation of reactive nitrogen species (RNS) leading to nitrosative stress (NSS) and aberrant protein S-nitrosylation contribute to NO toxicity. Studies have highlighted the involvement of NSS and S-nitrosylation in perturbing ER signaling through the modification of ER sensors and resident isomerases in neurons. This review focuses on the existing evidence that strongly associates NO with ERS and the possible implications in the context of ED induced by oxLDL and oxysterols. The potential effects of perturbed NO synthesis on signaling effectors linking NSS with ERS in endothelial cells are discussed to provide a conceptual framework for further in-vestigations and the development of novel therapeutic strategies targeting ED.

When nitrosative stress hits the endoplasmic reticulum. Possible implications in oxLDL/oxysterols-induced endothelial dysfunction / Nasoni, M G; Crinelli, R; Iuliano, L; Luchetti, F. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 208:(2023), pp. 178-185. [10.1016/j.freeradbiomed.2023.08.008]

When nitrosative stress hits the endoplasmic reticulum. Possible implications in oxLDL/oxysterols-induced endothelial dysfunction

Iuliano, L
Penultimo
Membro del Collaboration Group
;
2023

Abstract

Oxidized LDL (oxLDL) and oxysterols are known to play a crucial role in endothelial dysfunction (ED) by inducing endoplasmic reticulum stress (ERS), inflammation, and apoptosis. However, the precise molecular mechanisms underlying these pathophysiological processes remain incompletely understood. Emerging evidence strongly implicates excessive nitric oxide (NO) production in the progression of various pathological conditions. The accumulation of reactive nitrogen species (RNS) leading to nitrosative stress (NSS) and aberrant protein S-nitrosylation contribute to NO toxicity. Studies have highlighted the involvement of NSS and S-nitrosylation in perturbing ER signaling through the modification of ER sensors and resident isomerases in neurons. This review focuses on the existing evidence that strongly associates NO with ERS and the possible implications in the context of ED induced by oxLDL and oxysterols. The potential effects of perturbed NO synthesis on signaling effectors linking NSS with ERS in endothelial cells are discussed to provide a conceptual framework for further in-vestigations and the development of novel therapeutic strategies targeting ED.
2023
ER stress; endothelial dysfunction; nitric oxide; nitrosative stress; Ox-LDLs; oxysterols; s-nitrosylation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
When nitrosative stress hits the endoplasmic reticulum. Possible implications in oxLDL/oxysterols-induced endothelial dysfunction / Nasoni, M G; Crinelli, R; Iuliano, L; Luchetti, F. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 208:(2023), pp. 178-185. [10.1016/j.freeradbiomed.2023.08.008]
File allegati a questo prodotto
File Dimensione Formato  
Nasoni_Nitrosative-stress_2023.pdf

accesso aperto

Note: PDF FRBM 2023
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.07 MB
Formato Adobe PDF
2.07 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1687913
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 2
social impact