OBJECTIVE: COVID-19 clinical presentation ranges from asymptomatic infec-tion to an inflammatory cytokine storm with multi-organ failure and fatal outcomes. The identification of high-risk patients for severe disease is crucial to plan an early treatment and intensive follow-up. We aimed to investi-gate negative prognostic factors in a group of patients hospitalized for COVID-19. PATIENTS AND METHODS: 181 patients (90 men and 91 women, mean age 66.56 +/- 13.53 years) were enrolled. Each patient received a work-up in-cluding medical history, clinical examination, arte-rial blood gas analysis, laboratory blood tests, fea-sible ventilatory support required during hospital stay, intensive care setting required, duration of illness and length of hospital stay (> or < 25 days). For the assessment of the severity of COVID-19, three main indicators were considered: 1) the in-tensive care unit (ICU) admission 2) the hospital-ization length > 25 days; 3) the need of non-inva-sive ventilation (NIV). RESULTS: The independent risk factor associ-ated with the ICU admission were lactic dehydro-genase elevation (p=0.046), C reactive protein elevation (p=0.014) at hospital admission and di-rect oral anticoagulant home therapy (p=0.048); for hospital length > 25 days: early corticosteroid therapy (p=0.035); for NIV treatment: ferritin ele-vation at hospital admission (p=0.006). CONCLUSIONS: The presence of the above factors may be useful to identify patients at high risk of developing a severe COVID-19 that need an early treatment and intensive follow-up.

Analysis of prognostic factors in COVID-19 hospitalized patients. an italian single-center case-control study / Concistrè, A; Petramala, L; Pugliano, C L; Celi, M; Vinci, F; Assanto, E; Barchetta, I; Perrone, E P; Rella, S; Iannazzo, F; Angheloni, A; Coraggio, L; Di Rienzo, F; Maggi, D; Circosta, F; Galardo, G; Muscaritoli, M; Letizia, C. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 27:3(2023), pp. 1207-1221. [10.26355/eurrev_202302_31232]

Analysis of prognostic factors in COVID-19 hospitalized patients. an italian single-center case-control study

Petramala, L;Pugliano, C L;Assanto, E;Barchetta, I;Perrone, E P;Angheloni, A;Coraggio, L;Circosta, F;Galardo, G;Muscaritoli, M;Letizia, C
2023

Abstract

OBJECTIVE: COVID-19 clinical presentation ranges from asymptomatic infec-tion to an inflammatory cytokine storm with multi-organ failure and fatal outcomes. The identification of high-risk patients for severe disease is crucial to plan an early treatment and intensive follow-up. We aimed to investi-gate negative prognostic factors in a group of patients hospitalized for COVID-19. PATIENTS AND METHODS: 181 patients (90 men and 91 women, mean age 66.56 +/- 13.53 years) were enrolled. Each patient received a work-up in-cluding medical history, clinical examination, arte-rial blood gas analysis, laboratory blood tests, fea-sible ventilatory support required during hospital stay, intensive care setting required, duration of illness and length of hospital stay (> or < 25 days). For the assessment of the severity of COVID-19, three main indicators were considered: 1) the in-tensive care unit (ICU) admission 2) the hospital-ization length > 25 days; 3) the need of non-inva-sive ventilation (NIV). RESULTS: The independent risk factor associ-ated with the ICU admission were lactic dehydro-genase elevation (p=0.046), C reactive protein elevation (p=0.014) at hospital admission and di-rect oral anticoagulant home therapy (p=0.048); for hospital length > 25 days: early corticosteroid therapy (p=0.035); for NIV treatment: ferritin ele-vation at hospital admission (p=0.006). CONCLUSIONS: The presence of the above factors may be useful to identify patients at high risk of developing a severe COVID-19 that need an early treatment and intensive follow-up.
2023
COVID-19; SARS-CoV-2; prediction; lactic dehydrogenase; prognosis; ICU; hospitalization; NIV; C reactive protein; corticosteroid therapy; hospitalization
01 Pubblicazione su rivista::01a Articolo in rivista
Analysis of prognostic factors in COVID-19 hospitalized patients. an italian single-center case-control study / Concistrè, A; Petramala, L; Pugliano, C L; Celi, M; Vinci, F; Assanto, E; Barchetta, I; Perrone, E P; Rella, S; Iannazzo, F; Angheloni, A; Coraggio, L; Di Rienzo, F; Maggi, D; Circosta, F; Galardo, G; Muscaritoli, M; Letizia, C. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 27:3(2023), pp. 1207-1221. [10.26355/eurrev_202302_31232]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1687685
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