In Western countries, calcific aortic valve stenosis (CAS) is widely common, representing the third cause of death among cardiovascular diseases (CVD). The burden of CAS is high, with an increasing prevalence rate related to age. An efficient medical treatment, according to guidelines, lacks to prevent the development and to reduce the progression of CAS. In this context, due to the aging population and the lack of effective medical management, the prevalence is expected to double-triple within the next decades. In our review, we aim to provide an overview of the underlying mechanisms of pathogenesis and the current state of the art regarding pathophysiological insights and novel potential therapeutic targets.

The burden of calcific aortic stenosis. what's behind / Romiti, S; Vinciguerra, M; D'Abramo, M; Bruno, N; Miraldi, F; Gaudio, C; Greco, E. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 27:15(2023), pp. 7276-7288. [10.26355/eurrev_202308_33299]

The burden of calcific aortic stenosis. what's behind

Romiti, S
Primo
;
Vinciguerra, M;D'Abramo, M;Bruno, N;Miraldi, F;Gaudio, C
Penultimo
;
Greco, E
Ultimo
2023

Abstract

In Western countries, calcific aortic valve stenosis (CAS) is widely common, representing the third cause of death among cardiovascular diseases (CVD). The burden of CAS is high, with an increasing prevalence rate related to age. An efficient medical treatment, according to guidelines, lacks to prevent the development and to reduce the progression of CAS. In this context, due to the aging population and the lack of effective medical management, the prevalence is expected to double-triple within the next decades. In our review, we aim to provide an overview of the underlying mechanisms of pathogenesis and the current state of the art regarding pathophysiological insights and novel potential therapeutic targets.
2023
calcific aortic stenosis; atherosclerosis; aortic valve interstitial cell; lipid-lowering agents; antiresorptive agents; inflammation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The burden of calcific aortic stenosis. what's behind / Romiti, S; Vinciguerra, M; D'Abramo, M; Bruno, N; Miraldi, F; Gaudio, C; Greco, E. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 27:15(2023), pp. 7276-7288. [10.26355/eurrev_202308_33299]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1687366
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