Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic disease but induced by systemic ingestion or local use of some drugs. The present authors analyzed a case series of three case reports with clinical and pharmacological features compatible with the diagnosis of angiotensin converting enzyme inhibitors or angiotensin II receptor blocker drug-induced pemphigus. The patients were visited by the dermatological Unit of Magna Graecia University in Catanzaro. All suspected drug induced pemphigus were treated by suspending the suspected drug and by starting a treatment with systemic corticosteroid drugs, leading to a remission of the clinical manifestations in some months. When a drug induced bullous disease is probable, it is necessary to interrupt the suspected substance and to start a high dose treatment with corticosteroid drugs to resolve the clinical case in a short period of time

Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus. a case series and literature review / Palleria, C; Bennardo, L; Dastoli, S; Iannone, Lf; Silvestri, M; Manti, A; Russo, Emilio; Nisticò, Steven Paul; DE SARRO, Giovambattista. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - 32:1(2019). [10.1111/dth.12748]

Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus. a case series and literature review

Nisticò, Steven Paul;DE SARRO, GIOVAMBATTISTA
2019

Abstract

Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic disease but induced by systemic ingestion or local use of some drugs. The present authors analyzed a case series of three case reports with clinical and pharmacological features compatible with the diagnosis of angiotensin converting enzyme inhibitors or angiotensin II receptor blocker drug-induced pemphigus. The patients were visited by the dermatological Unit of Magna Graecia University in Catanzaro. All suspected drug induced pemphigus were treated by suspending the suspected drug and by starting a treatment with systemic corticosteroid drugs, leading to a remission of the clinical manifestations in some months. When a drug induced bullous disease is probable, it is necessary to interrupt the suspected substance and to start a high dose treatment with corticosteroid drugs to resolve the clinical case in a short period of time
2019
ACE inhibitors; ARBs; drug-induced pemphigus
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus. a case series and literature review / Palleria, C; Bennardo, L; Dastoli, S; Iannone, Lf; Silvestri, M; Manti, A; Russo, Emilio; Nisticò, Steven Paul; DE SARRO, Giovambattista. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - 32:1(2019). [10.1111/dth.12748]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1687267
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