The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted how urgent and necessary the discovery of new antiviral compounds is for novel therapeutic approaches. Among the various classes of molecules with antiviral activity, antimicrobial peptides (AMPs) of innate immunity are among the most promising ones, mainly due to their different mechanisms of action against viruses and additional biological properties. In this review, the main physicochemical characteristics of AMPs are described, with particular interest toward peptides derived from amphibian skin. Living in aquatic and terrestrial environments, amphibians are one of the richest sources of AMPs with different primary and secondary structures. Besides describing the various antiviral activities of these peptides and the underlying mechanism, this review aims at emphasizing the high potential of these small molecules for the development of new antiviral agents that likely reduce the selection of resistant strains.

Antimicrobial peptides for novel antiviral strategies in the current post-COVID-19 pandemic / Loffredo, Maria Rosa; Nencioni, Lucia; Mangoni, Maria Luisa; Casciaro, Bruno. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - (2023), pp. 1-28. [10.1002/psc.3534]

Antimicrobial peptides for novel antiviral strategies in the current post-COVID-19 pandemic

Loffredo, Maria Rosa
;
Nencioni, Lucia;Mangoni, Maria Luisa
;
Casciaro, Bruno
2023

Abstract

The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted how urgent and necessary the discovery of new antiviral compounds is for novel therapeutic approaches. Among the various classes of molecules with antiviral activity, antimicrobial peptides (AMPs) of innate immunity are among the most promising ones, mainly due to their different mechanisms of action against viruses and additional biological properties. In this review, the main physicochemical characteristics of AMPs are described, with particular interest toward peptides derived from amphibian skin. Living in aquatic and terrestrial environments, amphibians are one of the richest sources of AMPs with different primary and secondary structures. Besides describing the various antiviral activities of these peptides and the underlying mechanism, this review aims at emphasizing the high potential of these small molecules for the development of new antiviral agents that likely reduce the selection of resistant strains.
2023
antimicrobial peptides; antiviral activity; innate immunity; severe acute respiratory syndrome coronavirus 2
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Antimicrobial peptides for novel antiviral strategies in the current post-COVID-19 pandemic / Loffredo, Maria Rosa; Nencioni, Lucia; Mangoni, Maria Luisa; Casciaro, Bruno. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - (2023), pp. 1-28. [10.1002/psc.3534]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1686382
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