Approximately 20-50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have interrogated a heterogeneous set of primary colorectal cancer (CRC), liver CRC metastases and adjacent liver tissue to identify molecular determinants of the colon to liver spreading. Screening Food and Drug Administration (FDA) approved drugs for their ability to interfere with an identified colon to liver metastasis signature may help filling an unmet therapeutic need.

Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids / Cioce, M; Fumagalli, Mr; Donzelli, S; Goeman, F; Canu, V; Rutigliano, D; Orlandi, G; Sacconi, A; Pulito, C; Palcau, Ac; Fanciulli, M; Morrone, A; Diodoro, Mg; Caricato, M; Crescenzi, A; Verri, M; Fazio, Vm; Zapperi, S; Levrero, M; Strano, S; Grazi, Gl; La Porta, C; Blandino, G.. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 42:1(2023). [10.1186/s13046-023-02754-6]

Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids

Palcau AC;Crescenzi A;
2023

Abstract

Approximately 20-50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have interrogated a heterogeneous set of primary colorectal cancer (CRC), liver CRC metastases and adjacent liver tissue to identify molecular determinants of the colon to liver spreading. Screening Food and Drug Administration (FDA) approved drugs for their ability to interfere with an identified colon to liver metastasis signature may help filling an unmet therapeutic need.
2023
5-FU; CMAP; CRC; Chemoresistance; Desloratadine; Dexketoprofen; IL-6; Liver metastases; Organoids; Pentoxifylline; STAT3.
01 Pubblicazione su rivista::01a Articolo in rivista
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids / Cioce, M; Fumagalli, Mr; Donzelli, S; Goeman, F; Canu, V; Rutigliano, D; Orlandi, G; Sacconi, A; Pulito, C; Palcau, Ac; Fanciulli, M; Morrone, A; Diodoro, Mg; Caricato, M; Crescenzi, A; Verri, M; Fazio, Vm; Zapperi, S; Levrero, M; Strano, S; Grazi, Gl; La Porta, C; Blandino, G.. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 42:1(2023). [10.1186/s13046-023-02754-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1685493
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