There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessment, based on sex, age, smoking habits, systolic blood pressure, and total cholesterol levels. The 40-month cumulative incidence of CV-AEs was 25.2 +/- 8.1\%. Patients with the SCORE of high-very high showed a significantly higher incidence of CV-AEs (55 +/- 12.9\% vs 9 +/- 9.5\%; p=0.002). Overall, 9 CV-AEs were reported, with 2 deaths attributed to CV-AE. In conclusion, the SCORE assessment before starting treatment is helpful in identifying CV-AE high-risk patients during bosutinib treatment.
Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice / Caocci, Giovanni; Mulas, Olga; Abruzzese, Elisabetta; Iurlo, Alessandra; Annunziata, Mario; Maria Orlandi, Ester; Galimberti, Sara; Binotto, Gianni; Sgherza, Nicola; Luciano, Luigia; Martino, Bruno; Russo Rossi, Antonella; Bonifacio, Massimiliano; Fozza, Claudio; Monika Trawinska, Malgorzata; Cattaneo, Daniele; Elena, Chiara; Baratè, Claudia; De Gregorio, Fiorenza; Molica, Matteo; La Nasa, Giorgio; Robin, Foà; Breccia, Massimo. - In: ANNALS OF HEMATOLOGY. - ISSN 0939-5555. - 98:8(2019), pp. 1885-1890. [10.1007/s00277-019-03705-y]
Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice
Matteo Molica;Robin Foà;Massimo Breccia
2019
Abstract
There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessment, based on sex, age, smoking habits, systolic blood pressure, and total cholesterol levels. The 40-month cumulative incidence of CV-AEs was 25.2 +/- 8.1\%. Patients with the SCORE of high-very high showed a significantly higher incidence of CV-AEs (55 +/- 12.9\% vs 9 +/- 9.5\%; p=0.002). Overall, 9 CV-AEs were reported, with 2 deaths attributed to CV-AE. In conclusion, the SCORE assessment before starting treatment is helpful in identifying CV-AE high-risk patients during bosutinib treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
