Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell popula- tions, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evalu- ated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field.

The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? / Sciarra, Francesca; Franceschini, Edoardo; Campolo, Federica; Venneri, Mary Anna. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:13(2023), p. 10422. [10.3390/ijms241310422]

The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?

Sciarra, Francesca;Franceschini, Edoardo;Campolo, Federica;Venneri, Mary Anna
2023

Abstract

Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell popula- tions, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evalu- ated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field.
2023
human blood microbiome; bacteria; dysbiosis; prognostic marker; microbiome
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? / Sciarra, Francesca; Franceschini, Edoardo; Campolo, Federica; Venneri, Mary Anna. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:13(2023), p. 10422. [10.3390/ijms241310422]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1683968
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