The discovery of new bioactivities is closely related to the generation of novel scaffolds, and in the past few years different strategies have been proposed to obtain unknown architectures from the manipulation of known compounds. In the present study, we exploited a vintage photochemical approach for the discovery of an unexpected pathway of reactivity related to Delta 1-3-oxo-pentacyclic triterpenic acids gaining access to a new class of natural-unnatural 5(10 -> 1)abeo-pentacyclic triterpenic acids.
A Classic Photochemical Approach Inducing an Unexpected Rearrangement: Exploring the Photoreactivity of Pentacyclic Triterpenic Acids / Rogati, Federica; Maioli, Chiara; Lauro, Gianluigi; Caprioglio, Diego; Imperio, Daniela; Del Grosso, Erika; Botta, Bruno; Mannina, Luisa; Bifulco, Giuseppe; Ingallina, Cinzia; Minassi, Alberto. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 86:4(2023), pp. 1025-1032. [10.1021/acs.jnatprod.3c00067]
A Classic Photochemical Approach Inducing an Unexpected Rearrangement: Exploring the Photoreactivity of Pentacyclic Triterpenic Acids
Botta, Bruno;Mannina, Luisa;Ingallina, Cinzia
;
2023
Abstract
The discovery of new bioactivities is closely related to the generation of novel scaffolds, and in the past few years different strategies have been proposed to obtain unknown architectures from the manipulation of known compounds. In the present study, we exploited a vintage photochemical approach for the discovery of an unexpected pathway of reactivity related to Delta 1-3-oxo-pentacyclic triterpenic acids gaining access to a new class of natural-unnatural 5(10 -> 1)abeo-pentacyclic triterpenic acids.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
