The DNA repair protein Cockayne syndrome group B (CSB) is frequently found overexpressed in cancer cells. High CSB levels favor tumor cell proliferation whilst inhibiting apoptosis. Conversely, the suppression of CSB has significant anticancer effects. In this manuscript we describe CSB downregulation as a potential new therapeutic approach in cancer.
CSB: An Emerging Actionable Target for Cancer Therapy / Proietti-De-Santis, L.; Balzerano, A.; Prantera, G.. - In: TRENDS IN CANCER. - ISSN 2405-8033. - 4:3(2018), pp. 172-175. [10.1016/j.trecan.2018.01.005]
CSB: An Emerging Actionable Target for Cancer Therapy
Balzerano A.;Prantera G.
2018
Abstract
The DNA repair protein Cockayne syndrome group B (CSB) is frequently found overexpressed in cancer cells. High CSB levels favor tumor cell proliferation whilst inhibiting apoptosis. Conversely, the suppression of CSB has significant anticancer effects. In this manuscript we describe CSB downregulation as a potential new therapeutic approach in cancer.File allegati a questo prodotto
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