The hypoxia-inducible factor-1α (HIF-1α), a key player in the adaptive regulation of energy metabolism, and the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), a critical regulator of glucose consumption, are the main drivers of the metabolic rewiring in cancer cells. The use of glycolysis rather than oxidative phosphorylation, even in the presence of oxygen (i.e., Warburg effect or aerobic glycolysis), is a major metabolic hallmark of cancer. Aerobic glycolysis is also important for the immune system, which is involved in both metabolic disorders development and tumorigenesis. More recently, metabolic changes resembling the Warburg effect have been described in diabetes mellitus (DM). Scientists from different disciplines are looking for ways to interfere with these cellular metabolic rearrangements and reverse the pathological processes underlying their disease of interest. As cancer is overtaking cardiovascular disease as the leading cause of excess death in DM, and biological links between DM and cancer are incompletely understood, cellular glucose metabolism may be a promising field to explore in search of connections between cardiometabolic and cancer diseases. In this mini-review, we present the state-of-the-art on the role of the Warburg effect, HIF-1α, and PKM2 in cancer, inflammation, and DM to encourage multidisciplinary research to advance fundamental understanding in biology and pathways implicated in the link between DM and cancer.

The "sweet" path to cancer. focus on cellular glucose metabolism / Iacobini, Carla; Vitale, Martina; Pugliese, Giuseppe; Menini, Stefano. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 13:(2023), pp. 1-8. [10.3389/fonc.2023.1202093]

The "sweet" path to cancer. focus on cellular glucose metabolism

Iacobini, Carla
Primo
Writing – Original Draft Preparation
;
Vitale, Martina
Secondo
;
Pugliese, Giuseppe
Penultimo
;
Menini, Stefano
Ultimo
Writing – Original Draft Preparation
2023

Abstract

The hypoxia-inducible factor-1α (HIF-1α), a key player in the adaptive regulation of energy metabolism, and the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), a critical regulator of glucose consumption, are the main drivers of the metabolic rewiring in cancer cells. The use of glycolysis rather than oxidative phosphorylation, even in the presence of oxygen (i.e., Warburg effect or aerobic glycolysis), is a major metabolic hallmark of cancer. Aerobic glycolysis is also important for the immune system, which is involved in both metabolic disorders development and tumorigenesis. More recently, metabolic changes resembling the Warburg effect have been described in diabetes mellitus (DM). Scientists from different disciplines are looking for ways to interfere with these cellular metabolic rearrangements and reverse the pathological processes underlying their disease of interest. As cancer is overtaking cardiovascular disease as the leading cause of excess death in DM, and biological links between DM and cancer are incompletely understood, cellular glucose metabolism may be a promising field to explore in search of connections between cardiometabolic and cancer diseases. In this mini-review, we present the state-of-the-art on the role of the Warburg effect, HIF-1α, and PKM2 in cancer, inflammation, and DM to encourage multidisciplinary research to advance fundamental understanding in biology and pathways implicated in the link between DM and cancer.
2023
warburg effect; aerobic glycolysis; diabetes mellitus; hypoxia inducible factor (hif)-1α; inflammation; methylglyoxal (mgo); oxidative phoshorylation; pyruvate kinase m isoform 2
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The "sweet" path to cancer. focus on cellular glucose metabolism / Iacobini, Carla; Vitale, Martina; Pugliese, Giuseppe; Menini, Stefano. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 13:(2023), pp. 1-8. [10.3389/fonc.2023.1202093]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1683467
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