The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello cv. were extracted in a Soxhlet apparatus, using n-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed in vitro as wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively. n-hexane Mantonico extract resulted in the most interesting wound healing sample, while n-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties.

Mantonico and Pecorello grape seed extracts. Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities / Carullo, G.; Sciubba, F.; Governa, P.; Mazzotta, S.; Frattaruolo, L.; Grillo, G.; Cappello, A. R.; Cravotto, G.; Di Cocco, M. E.; Aiello, F.. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 13:5(2020), pp. 1-12. [10.3390/ph13050097]

Mantonico and Pecorello grape seed extracts. Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities

Sciubba F.;Mazzotta S.;Di Cocco M. E.;
2020

Abstract

The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello cv. were extracted in a Soxhlet apparatus, using n-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed in vitro as wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively. n-hexane Mantonico extract resulted in the most interesting wound healing sample, while n-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties.
2020
anti-inflammatory; carotenoids; GC-MS; grape seeds; HaCaT cell line; lipophilic fraction; NMR; RAW 264.7 cell line; soxhlet; wound healing
01 Pubblicazione su rivista::01a Articolo in rivista
Mantonico and Pecorello grape seed extracts. Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities / Carullo, G.; Sciubba, F.; Governa, P.; Mazzotta, S.; Frattaruolo, L.; Grillo, G.; Cappello, A. R.; Cravotto, G.; Di Cocco, M. E.; Aiello, F.. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 13:5(2020), pp. 1-12. [10.3390/ph13050097]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1683008
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