Fatty acids and polyphenols represent different classes of pharmacologically active molecules. Hybrid derivatives of these compounds are interesting therapeutic tools. They could be obtained using enzymatic approaches, which allow regioselective derivatizations. In this short note, the pancreatic porcine lipase was employed to mediate the regioselective synthesis of 7-docosahexaenoyl-quercetin was described. The C-7 regioisomer formation was confirmed by 1H-NMR experiment. Generally, in this approach the alcoholic OH- was preferred when present. Nevertheless, in this case, it was demonstrated that the hindrance of the acyl group is a variable to obtain a good regioselectivity in C-7 position, employing only one-step reaction.
7-Docosahexaenoyl-Quercetin / Mazzotta, Sarah; Carullo, Gabriele; Sciubba, Fabio; DI COCCO, Maria Enrica; Aiello, FRANCESCA ANTONELLA. - In: MOLBANK. - ISSN 1422-8599. - 2021:2(2021), pp. 1-4. [10.3390/M1203]
7-Docosahexaenoyl-Quercetin
Fabio Sciubba;Maria Enrica Di Cocco;Francesca Aiello
2021
Abstract
Fatty acids and polyphenols represent different classes of pharmacologically active molecules. Hybrid derivatives of these compounds are interesting therapeutic tools. They could be obtained using enzymatic approaches, which allow regioselective derivatizations. In this short note, the pancreatic porcine lipase was employed to mediate the regioselective synthesis of 7-docosahexaenoyl-quercetin was described. The C-7 regioisomer formation was confirmed by 1H-NMR experiment. Generally, in this approach the alcoholic OH- was preferred when present. Nevertheless, in this case, it was demonstrated that the hindrance of the acyl group is a variable to obtain a good regioselectivity in C-7 position, employing only one-step reaction.File | Dimensione | Formato | |
---|---|---|---|
Mazzotta_7-Docosahexaenoyl-Quercetin_2021.pdf
accesso aperto
Note: Articolo rivista
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
470.58 kB
Formato
Adobe PDF
|
470.58 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.