Introduction: Advances in the management of intestinal failure have led to a reduction in the number of intestinal transplants. The number of bowel transplants has been mainly stable even though a slight increase has been observed in the last five years. Areas covered: Standard indication includes patients with a reasonable life expectancy. Recent progress can be deduced by the increased number of intestine transplants in adults: this is due to the continuous improvement of 1- year graft survival worldwide (without differences in 3- and 5-year) associated with better abdominal wall closure techniques. This review aims to provide an update on new indications and changes in trends of pediatric and adult intestine transplantation. This analysis, which stretches through the past 5 years, is based on a collection of related manuscripts from PubMed. Expert commentary: Intestinal transplants should be solely intended for a group of individuals for whom indications for transplantation are clear and both medical and surgical rehabilitations have failed. Nevertheless, the many protocols developed over the years have not yet solved the key question represented by the over-immunosuppression. Novel indications and recent progress in the bowel transplant field, minimal yet consistent, represent a pathway to be followed.

Small bowel transplant – novel indications and recent progress / Zorzetti, Noemi; Marino, Ignazio Roberto; Sorrenti, Salvatore; Navarra, Giuseppe Giovanni; D'Andrea, Vito; Lauro, Augusto. - In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1747-4132. - (2023). [10.1080/17474124.2023.2221433]

Small bowel transplant – novel indications and recent progress

Zorzetti, Noemi;Marino, Ignazio Roberto;Sorrenti, Salvatore;D'Andrea, Vito;Lauro, Augusto
Ultimo
Writing – Review & Editing
2023

Abstract

Introduction: Advances in the management of intestinal failure have led to a reduction in the number of intestinal transplants. The number of bowel transplants has been mainly stable even though a slight increase has been observed in the last five years. Areas covered: Standard indication includes patients with a reasonable life expectancy. Recent progress can be deduced by the increased number of intestine transplants in adults: this is due to the continuous improvement of 1- year graft survival worldwide (without differences in 3- and 5-year) associated with better abdominal wall closure techniques. This review aims to provide an update on new indications and changes in trends of pediatric and adult intestine transplantation. This analysis, which stretches through the past 5 years, is based on a collection of related manuscripts from PubMed. Expert commentary: Intestinal transplants should be solely intended for a group of individuals for whom indications for transplantation are clear and both medical and surgical rehabilitations have failed. Nevertheless, the many protocols developed over the years have not yet solved the key question represented by the over-immunosuppression. Novel indications and recent progress in the bowel transplant field, minimal yet consistent, represent a pathway to be followed.
2023
intestinal transplantation; enteral autonomy; home parenteral nutrition; intestinal failure; quality of life; short bowel syndrome
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Small bowel transplant – novel indications and recent progress / Zorzetti, Noemi; Marino, Ignazio Roberto; Sorrenti, Salvatore; Navarra, Giuseppe Giovanni; D'Andrea, Vito; Lauro, Augusto. - In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1747-4132. - (2023). [10.1080/17474124.2023.2221433]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1682304
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