This monocentric, retrospective, two-stage observational study aimed to recognize the risk factors for a poor outcome in patients hospitalized with SARS-CoV-2 infection, and to develop and validate a risk score that identifies subjects at risk of worsening, death, or both. The data of patients with SARS-CoV-2 infection during the first wave of the pandemic were collected and analyzed as a derivation cohort. Variables with predictive properties were used to construct a prognostic score, which was tried out on a validation cohort enrolled during the second wave. The derivation cohort included 494 patients; the median age was 62 and the overall fatality rate was 22.3%. In a multivariable analysis, age, oxygen saturation, neutrophil-to-lymphocyte ratio, C-reactive protein and lactate dehydrogenase were independent predictors of death and composed the score. A cutoff value of 3 demonstrated a sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of 93.5%, 68.5%, 47.4% and 97.2% for death, and 84.9%, 84.5%, 79.6% and 87.9% for worsening, respectively. The validation cohort included 415 subjects. The score application showed a Se, Sp, PPV and NPV of 93.4%, 61.6%, 29.5% and 98.1% for death, and 81%, 76.3%, 72.1% and 84.1% for worsening, respectively. We propose a new clinical, easy and reliable score to predict the outcome in hospitalized SARS-CoV-2 patients.

Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score / Cruciata, A.; Volpicelli, L.; Di Bari, S.; Iaiani, G.; Cirillo, B.; Pugliese, F.; Pellegrino, D.; Galardo, G.; Taliani, G.. - In: VIRUSES. - ISSN 1999-4915. - 14:3(2022). [10.3390/v14030642]

Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score

Cruciata A.;Volpicelli L.;Cirillo B.;Pugliese F.;Galardo G.;Taliani G.
2022

Abstract

This monocentric, retrospective, two-stage observational study aimed to recognize the risk factors for a poor outcome in patients hospitalized with SARS-CoV-2 infection, and to develop and validate a risk score that identifies subjects at risk of worsening, death, or both. The data of patients with SARS-CoV-2 infection during the first wave of the pandemic were collected and analyzed as a derivation cohort. Variables with predictive properties were used to construct a prognostic score, which was tried out on a validation cohort enrolled during the second wave. The derivation cohort included 494 patients; the median age was 62 and the overall fatality rate was 22.3%. In a multivariable analysis, age, oxygen saturation, neutrophil-to-lymphocyte ratio, C-reactive protein and lactate dehydrogenase were independent predictors of death and composed the score. A cutoff value of 3 demonstrated a sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of 93.5%, 68.5%, 47.4% and 97.2% for death, and 84.9%, 84.5%, 79.6% and 87.9% for worsening, respectively. The validation cohort included 415 subjects. The score application showed a Se, Sp, PPV and NPV of 93.4%, 61.6%, 29.5% and 98.1% for death, and 81%, 76.3%, 72.1% and 84.1% for worsening, respectively. We propose a new clinical, easy and reliable score to predict the outcome in hospitalized SARS-CoV-2 patients.
2022
COVID-19; SARS-CoV-2; clinical score; prognostic score; risk of death; risk of worsening
01 Pubblicazione su rivista::01a Articolo in rivista
Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score / Cruciata, A.; Volpicelli, L.; Di Bari, S.; Iaiani, G.; Cirillo, B.; Pugliese, F.; Pellegrino, D.; Galardo, G.; Taliani, G.. - In: VIRUSES. - ISSN 1999-4915. - 14:3(2022). [10.3390/v14030642]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1682195
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