Background Non-invasive diagnostic techniques in dermatology gained increasing popularity in the last decade. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are meanwhile established in research and clinical routine. While OCT is mainly indicated for detecting non-melanoma skin cancer, RCM has proven its usefulness additionally in distinguishing melanocytic lesions. Line-field confocal optical coherence tomography (LC-OCT) is an emerging tool combining the principles of both above-mentioned methods. Methods Healthy skin at different body sites and exemplary skin lesions (basal cell carcinoma, malignant melanoma, actinic keratosis) were examined using dermoscopy, RCM, OCT and LC-OCT. Standard features for RCM and OCT and comparable features for LC-OCT were analysed. Results LC-OCT has a lower penetration depth but superior resolution compared to OCT. In comparison with RCM, which provides only horizontal sections, LC-OCT creates both vertical and horizontal images in real time and has nearly the same cellular resolution. Discussion Our preliminary experiences suggest that LC-OCT combines the advantages of RCM and OCT, with optimal resolution and penetration depth to diagnose all types of skin cancer. Larger systematic studies are needed to further characterize the field of use of this device and its sensitivity and specificity compared to histology.

Line-field confocal optical coherence tomography-practical applications in dermatology and comparison with established imaging methods / Ruini, Cristel; Schuh, Sandra; Sattler, Elke; Welzel, Julia. - In: SKIN RESEARCH AND TECHNOLOGY. - ISSN 0909-752X. - 27:3(2021), pp. 340-352. [10.1111/srt.12949]

Line-field confocal optical coherence tomography-practical applications in dermatology and comparison with established imaging methods

Ruini, Cristel;
2021

Abstract

Background Non-invasive diagnostic techniques in dermatology gained increasing popularity in the last decade. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are meanwhile established in research and clinical routine. While OCT is mainly indicated for detecting non-melanoma skin cancer, RCM has proven its usefulness additionally in distinguishing melanocytic lesions. Line-field confocal optical coherence tomography (LC-OCT) is an emerging tool combining the principles of both above-mentioned methods. Methods Healthy skin at different body sites and exemplary skin lesions (basal cell carcinoma, malignant melanoma, actinic keratosis) were examined using dermoscopy, RCM, OCT and LC-OCT. Standard features for RCM and OCT and comparable features for LC-OCT were analysed. Results LC-OCT has a lower penetration depth but superior resolution compared to OCT. In comparison with RCM, which provides only horizontal sections, LC-OCT creates both vertical and horizontal images in real time and has nearly the same cellular resolution. Discussion Our preliminary experiences suggest that LC-OCT combines the advantages of RCM and OCT, with optimal resolution and penetration depth to diagnose all types of skin cancer. Larger systematic studies are needed to further characterize the field of use of this device and its sensitivity and specificity compared to histology.
2021
dermatology; line-field confocal OCT; optical coherence tomography; reflectance confocal microscopy; skin cancer; skin imaging; humans; microscopy; confocal; tomography; optical coherence; carcinoma; basal cell; dermatology; melanoma; skin neoplasms
01 Pubblicazione su rivista::01a Articolo in rivista
Line-field confocal optical coherence tomography-practical applications in dermatology and comparison with established imaging methods / Ruini, Cristel; Schuh, Sandra; Sattler, Elke; Welzel, Julia. - In: SKIN RESEARCH AND TECHNOLOGY. - ISSN 0909-752X. - 27:3(2021), pp. 340-352. [10.1111/srt.12949]
File allegati a questo prodotto
File Dimensione Formato  
Ruini_Line-Field_2021.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 5.3 MB
Formato Adobe PDF
5.3 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1682127
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 58
  • ???jsp.display-item.citation.isi??? 58
social impact