A growing number of studies shows that it is possible to induce a phenotypic transformation of cancer cells from malignant to benign. This process is currently known as "tumor reversion". However, the concept of reversibility hardly fits the current cancer models, according to which gene mutations are considered the primary cause of cancer. Indeed, if gene mutations are causative carcinogenic factors, and if gene mutations are irreversible, how long should cancer be considered as an irreversible process? In fact, there is some evidence that intrinsic plasticity of cancerous cells may be therapeutically exploited to promote a phenotypic reprogramming, both in vitro and in vivo. Not only are studies on tumor reversion highlighting a new, exciting research approach, but they are also pushing science to look for new epistemological tools capable of better modeling cancer.

Is Cancer Reversible? Rethinking Carcinogenesis Models-A New Epistemological Tool / Pensotti, Andrea; Bertolaso, Marta; Bizzarri, Mariano. - In: BIOMOLECULES. - ISSN 2218-273X. - 13:5(2023), p. 733. [10.3390/biom13050733]

Is Cancer Reversible? Rethinking Carcinogenesis Models-A New Epistemological Tool

Bizzarri, Mariano
Conceptualization
2023

Abstract

A growing number of studies shows that it is possible to induce a phenotypic transformation of cancer cells from malignant to benign. This process is currently known as "tumor reversion". However, the concept of reversibility hardly fits the current cancer models, according to which gene mutations are considered the primary cause of cancer. Indeed, if gene mutations are causative carcinogenic factors, and if gene mutations are irreversible, how long should cancer be considered as an irreversible process? In fact, there is some evidence that intrinsic plasticity of cancerous cells may be therapeutically exploited to promote a phenotypic reprogramming, both in vitro and in vivo. Not only are studies on tumor reversion highlighting a new, exciting research approach, but they are also pushing science to look for new epistemological tools capable of better modeling cancer.
2023
biological network; embryo development; microenvironment; morphogenesis; systems biology; tumor reversion
01 Pubblicazione su rivista::01a Articolo in rivista
Is Cancer Reversible? Rethinking Carcinogenesis Models-A New Epistemological Tool / Pensotti, Andrea; Bertolaso, Marta; Bizzarri, Mariano. - In: BIOMOLECULES. - ISSN 2218-273X. - 13:5(2023), p. 733. [10.3390/biom13050733]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1682047
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