This study aims to retrospectively assess the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022, and to evaluate the influence of different risk factors. The department’s database and medical records from 2015 to 2022 were searched for patients with a confirmed diagnosis of OLP based on both clinical and histological parameters. A total of 100 patients (59 females and 41 males) were found with a mean age of 64.03 years. In the considered period, the percentage of diagnosed OLP patients was 1.6%, while the percentage of diagnosed OLP patients with transformation to oral squamous cell carcinoma (OSCC) was 0.18%. A statistically significant difference was found with age (p = 0.038), tobacco status (p = 0.022), and radiotherapy (p = 0.041). The analysis revealed the presence of significant risk in ex-smokers (>20 pack-years), with an odds ratio (OR) of 10.0000 (95% confidence interval (95% CI) 1.5793–63.3186); in alcohol-drinker patients, with an OR of 4.0519 (95% CI 1.0182–16.1253); in ex-smoker and alcohol-drinker patients, with OR of 17.6250 (95% CI 2.2464–138.2808); and in patients who had undergone radiotherapy, with OR of 6.3000 (95% CI 1.2661–31.3484). The malignant transformation of oral lichen planus was slightly higher than thought, and the results revealed a possible association with age, tobacco and alcohol status, and history of radiotherapy. An elevated risk of malignant transformation was observed in heavy ex-smoker patients, alcohol-drinker patients, and alcohol-drinker patients with a history of smoking (ex-smokers). Persuading the patient to quit tobacco and alcohol consumption and periodic follow-ups are recommended in general, but par-ticularly in the presence of these risk factors.

Risk of oral squamous cell carcinoma in one hundred patients with oral Lichen Planus: a follow-up study of Umberto I University Hospital of Rome / Tenore, Gianluca; Mohsen, AHMED AMIR MOHAMED; Rocchetti, Federica; Rossi, Giulia; Cassoni, Andrea; Battisti, Andrea; Della Monaca, Marco; DI GIOIA, Cira Rosaria Tiziana; DE FELICE, Francesca; Botticelli, Andrea; Valentini, Valentino; DELLA ROCCA, Carlo; DE VINCENTIIS, Marco; Polimeni, Antonella; Romeo, Umberto. - In: CANCERS. - ISSN 2072-6694. - 15:11(2023). [10.3390/cancers15113004]

Risk of oral squamous cell carcinoma in one hundred patients with oral Lichen Planus: a follow-up study of Umberto I University Hospital of Rome

Gianluca Tenore
Primo
;
Ahmed Mohsen
Secondo
;
Federica Rocchetti
;
Andrea Cassoni;Andrea Battisti;Marco Della Monaca;Cira Rosaria Tiziana Di Gioia;Francesca De Felice;Andrea Botticelli;Valentino Valentini;Carlo Della Rocca;Marco De Vincentiis;Antonella Polimeni
Penultimo
;
Umberto Romeo
Ultimo
2023

Abstract

This study aims to retrospectively assess the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022, and to evaluate the influence of different risk factors. The department’s database and medical records from 2015 to 2022 were searched for patients with a confirmed diagnosis of OLP based on both clinical and histological parameters. A total of 100 patients (59 females and 41 males) were found with a mean age of 64.03 years. In the considered period, the percentage of diagnosed OLP patients was 1.6%, while the percentage of diagnosed OLP patients with transformation to oral squamous cell carcinoma (OSCC) was 0.18%. A statistically significant difference was found with age (p = 0.038), tobacco status (p = 0.022), and radiotherapy (p = 0.041). The analysis revealed the presence of significant risk in ex-smokers (>20 pack-years), with an odds ratio (OR) of 10.0000 (95% confidence interval (95% CI) 1.5793–63.3186); in alcohol-drinker patients, with an OR of 4.0519 (95% CI 1.0182–16.1253); in ex-smoker and alcohol-drinker patients, with OR of 17.6250 (95% CI 2.2464–138.2808); and in patients who had undergone radiotherapy, with OR of 6.3000 (95% CI 1.2661–31.3484). The malignant transformation of oral lichen planus was slightly higher than thought, and the results revealed a possible association with age, tobacco and alcohol status, and history of radiotherapy. An elevated risk of malignant transformation was observed in heavy ex-smoker patients, alcohol-drinker patients, and alcohol-drinker patients with a history of smoking (ex-smokers). Persuading the patient to quit tobacco and alcohol consumption and periodic follow-ups are recommended in general, but par-ticularly in the presence of these risk factors.
2023
alcohol; malignant transformation; oral cancer; oral lichen planus; oral squamous cell carcinoma; smoking; tobacco
01 Pubblicazione su rivista::01a Articolo in rivista
Risk of oral squamous cell carcinoma in one hundred patients with oral Lichen Planus: a follow-up study of Umberto I University Hospital of Rome / Tenore, Gianluca; Mohsen, AHMED AMIR MOHAMED; Rocchetti, Federica; Rossi, Giulia; Cassoni, Andrea; Battisti, Andrea; Della Monaca, Marco; DI GIOIA, Cira Rosaria Tiziana; DE FELICE, Francesca; Botticelli, Andrea; Valentini, Valentino; DELLA ROCCA, Carlo; DE VINCENTIIS, Marco; Polimeni, Antonella; Romeo, Umberto. - In: CANCERS. - ISSN 2072-6694. - 15:11(2023). [10.3390/cancers15113004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1681660
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