Hydrogen sulfide delivery nanotechnologies in wound healing: The sulfurous thermal spring water potential on a dressing

The multiple positive effects of hydrogen sulfide on several pathologies and health threating conditions are well established. The efficacy of an exogenous supply of this gas- transmitter is related to the advantages represented by its pre-existing endogenous synthesis by enzymes present in all human tissues, skin included. These chemical patterns represent the main support to the medical effectiveness of sulfurous thermal spring waters in different health pathologies and skin ailments. Hard to heal-chronic wounds represent an increasing economic and social burden. Several studies analyzed the advantages of hydrogen sulfide delivery on wounds despite their etiologies. Being a volatile molecule, hydrogen sulfide is difficultly delivered by conventional dressings whereas Nano technology and nano-carriers may represent the perfect example of translational application. Here, we present a systematic review of available hydrogen sulfide nano-dressings for wound healing purposes aimed at evaluating the effectiveness of this extremely technological dressing miming the natural healing effect of sulfurous spring thermal water.