: The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.

Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine / Garofalo, Stefano; Cocozza, Germana; Mormino, Alessandro; Bernardini, Giovanni; Russo, Eleonora; Ielpo, Donald; Andolina, Diego; Ventura, Rossella; Martinello, Katiuscia; Renzi, Massimiliano; Fucile, Sergio; Laffranchi, Mattia; Mortari, Eva Piano; Carsetti, Rita; Sciumè, Giuseppe; Sozzani, Silvano; Santoni, Angela; Tremblay, Marie-Eve; Ransohoff, Richard M; Limatola, Cristina. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 14:1(2023), p. 3103. [10.1038/s41467-023-38899-3]

Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

Garofalo, Stefano
Primo
;
Cocozza, Germana;Mormino, Alessandro;Bernardini, Giovanni
Membro del Collaboration Group
;
Russo, Eleonora
Membro del Collaboration Group
;
Ielpo, Donald;Andolina, Diego;Ventura, Rossella
Membro del Collaboration Group
;
Renzi, Massimiliano;Fucile, Sergio;Laffranchi, Mattia;Mortari, Eva Piano;Sciumè, Giuseppe;Sozzani, Silvano;Santoni, Angela;Limatola, Cristina
2023

Abstract

: The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.
2023
natural killer (NK) cells and innate lymphoid cells; animal models
01 Pubblicazione su rivista::01a Articolo in rivista
Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine / Garofalo, Stefano; Cocozza, Germana; Mormino, Alessandro; Bernardini, Giovanni; Russo, Eleonora; Ielpo, Donald; Andolina, Diego; Ventura, Rossella; Martinello, Katiuscia; Renzi, Massimiliano; Fucile, Sergio; Laffranchi, Mattia; Mortari, Eva Piano; Carsetti, Rita; Sciumè, Giuseppe; Sozzani, Silvano; Santoni, Angela; Tremblay, Marie-Eve; Ransohoff, Richard M; Limatola, Cristina. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 14:1(2023), p. 3103. [10.1038/s41467-023-38899-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1681565
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