To date, no comprehensive marker to monitor the immune status of patients is available. Given that Torque teno virus (TTV), a known human virome component, has previously been identified as a marker of immunocompetence, it was retrospectively investigated whether TTV viral load may also represent a marker of ability to develop antibody in response to COVID-19-BNT162B2 vaccine in solid organ transplant recipients (SOT). Specifically, 273 samples from 146 kidney and 26 lung transplant recipients after successive doses of vaccine were analyzed. An inverse correlation was observed within the TTV copy number and anti-Spike IgG antibody titer with a progressive decrease in viremia the further away from the transplant date. Analyzing the data obtained after the second dose, a significant difference in TTV copy number between responsive and nonresponsive patients was observed, considering a 5 log10 TTV copies/mL threshold to discriminate between the two groups. Moreover, for 86 patients followed in their response to the second and third vaccination doses a 6 log10 TTV copies/mL threshold was used to predict responsivity to the booster dose. Although further investigation is necessary, possibly extending the analysis to other patient categories, this study suggests that TTV can be used as a good marker of vaccine response in transplant patients.

Torque teno virus (TTV): A gentle spy virus of immune status, predictive marker of seroconversion to COVID-19 vaccine in kidney and lung transplant recipients / Roberto, P.; Cinti, L.; Napoli, A.; Paesani, D.; Riveros Cabral, R. J.; Maggi, F.; Garofalo, M.; Pretagostini, R.; Centofanti, A.; Carillo, C.; Venuta, F.; Gaeta, A.; Antonelli, G.. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 1096-9071. - 95:2(2023). [10.1002/jmv.28512]

Torque teno virus (TTV): A gentle spy virus of immune status, predictive marker of seroconversion to COVID-19 vaccine in kidney and lung transplant recipients

Roberto P.;Cinti L.;Napoli A.;Riveros Cabral R. J.;Garofalo M.;Pretagostini R.;Centofanti A.;Carillo C.;Venuta F.;Gaeta A.;Antonelli G.
2023

Abstract

To date, no comprehensive marker to monitor the immune status of patients is available. Given that Torque teno virus (TTV), a known human virome component, has previously been identified as a marker of immunocompetence, it was retrospectively investigated whether TTV viral load may also represent a marker of ability to develop antibody in response to COVID-19-BNT162B2 vaccine in solid organ transplant recipients (SOT). Specifically, 273 samples from 146 kidney and 26 lung transplant recipients after successive doses of vaccine were analyzed. An inverse correlation was observed within the TTV copy number and anti-Spike IgG antibody titer with a progressive decrease in viremia the further away from the transplant date. Analyzing the data obtained after the second dose, a significant difference in TTV copy number between responsive and nonresponsive patients was observed, considering a 5 log10 TTV copies/mL threshold to discriminate between the two groups. Moreover, for 86 patients followed in their response to the second and third vaccination doses a 6 log10 TTV copies/mL threshold was used to predict responsivity to the booster dose. Although further investigation is necessary, possibly extending the analysis to other patient categories, this study suggests that TTV can be used as a good marker of vaccine response in transplant patients.
2023
BNT162B2 vaccine; SOT patients; TTV; kidney transplant; lung transplant
01 Pubblicazione su rivista::01a Articolo in rivista
Torque teno virus (TTV): A gentle spy virus of immune status, predictive marker of seroconversion to COVID-19 vaccine in kidney and lung transplant recipients / Roberto, P.; Cinti, L.; Napoli, A.; Paesani, D.; Riveros Cabral, R. J.; Maggi, F.; Garofalo, M.; Pretagostini, R.; Centofanti, A.; Carillo, C.; Venuta, F.; Gaeta, A.; Antonelli, G.. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 1096-9071. - 95:2(2023). [10.1002/jmv.28512]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1680310
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