Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.
Impact of ifn-free and ifn-based treatment on blood myeloid dendritic cell, monocyte, slan-dc, and activated t lymphocyte dynamics during hcv infection / Vita, S.; Zuccala, P.; Savinelli, S.; Mascia, C.; Rossi, R.; Schiavone, F.; Marocco, R.; Tieghi, T.; Iannetta, M.; Nijhawan, P.; Zingaropoli, M. A.; D'Ettore, G.; Vullo, V.; Mastroianni, C. M.; Lichtner, M.. - In: JOURNAL OF IMMUNOLOGY RESEARCH. - ISSN 2314-7156. - 2020:(2020), pp. 1-11. [10.1155/2020/2781350]
Impact of ifn-free and ifn-based treatment on blood myeloid dendritic cell, monocyte, slan-dc, and activated t lymphocyte dynamics during hcv infection
Vita S.
;Savinelli S.;Mascia C.;Tieghi T.;Iannetta M.;Nijhawan P.;Zingaropoli M. A.;Vullo V.;Mastroianni C. M.;Lichtner M.
2020
Abstract
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.File | Dimensione | Formato | |
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Note: Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection
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