Background: Since its outbreak, Coronavirus disease 2019 (COVID-19), a life-threatening respiratory illness, has rapidly become a public health emergency with a devastating social impact. Lately, the Omicron strain is considered the main variant of concern. Routine blood biomarkers are, indeed, essential for stratifying patients at risk of severe outcomes, and a huge amount of data is available in the literature, mainly for the previous variants. However, only a few studies are available on early routine biochemical blood biomarkers for Omicron-afflicted patients. Thus, the aim and novelty of this study were to identify routine blood biomarkers detected at the emergency room for the early prediction of severe morbidity and/or mortality. Methods: 449 COVID-19 patients from Sapienza University Hospital of Rome were divided into four groups: (1) the emergency group (patients with mild forms who were quickly discharged); (2) the hospital ward group (patients that after the admission in the emergency department were hospitalized in a COVID-19 ward); (3) the intensive care unit (ICU) group (patients that after the admission in the emergency department required intensive assistance); (4) the deceased group (patients that after the admission in the emergency department had a fatal outcome). Results: ANOVA and ROC data showed that high-sensitivity troponin-T (TnT), fibrinogen, glycemia, C-reactive protein, lactate dehydrogenase, albumin, D-dimer myoglobin, and ferritin for both men and women may predict lethal outcomes already at the level of the emergency department. Conclusions: Compared to previous Delta COVID-19 parallel emergency patterns of prediction, Omicron-induced changes in TnT may be considered other early predictors of severe outcomes.

Blood biomarkers from the emergency department disclose severe omicron covid-19-associated outcomes / Pennacchia, Fiorenza; Rusi, Eqrem; Ruqa, Wael Abu; Zingaropoli, Maria Antonella; Pasculli, Patrizia; Talarico, Giuseppina; Bruno, Giuseppe; Barbato, Christian; Minni, Antonio; Tarani, Luigi; Galardo, Gioacchino; Pugliese, Francesco; Lucarelli, Marco; Ferraguti, Giampiero; Ciardi, Maria Rosa; Fiore, Marco. - In: MICROORGANISMS. - ISSN 2076-2607. - 11:4(2023), pp. 1-21. [10.3390/microorganisms11040925]

Blood biomarkers from the emergency department disclose severe omicron covid-19-associated outcomes

Ruqa, Wael Abu;Zingaropoli, Maria Antonella;Pasculli, Patrizia;Talarico, Giuseppina;Bruno, Giuseppe;Minni, Antonio;Tarani, Luigi;Galardo, Gioacchino;Pugliese, Francesco;Lucarelli, Marco;Ferraguti, Giampiero
;
Ciardi, Maria Rosa;
2023

Abstract

Background: Since its outbreak, Coronavirus disease 2019 (COVID-19), a life-threatening respiratory illness, has rapidly become a public health emergency with a devastating social impact. Lately, the Omicron strain is considered the main variant of concern. Routine blood biomarkers are, indeed, essential for stratifying patients at risk of severe outcomes, and a huge amount of data is available in the literature, mainly for the previous variants. However, only a few studies are available on early routine biochemical blood biomarkers for Omicron-afflicted patients. Thus, the aim and novelty of this study were to identify routine blood biomarkers detected at the emergency room for the early prediction of severe morbidity and/or mortality. Methods: 449 COVID-19 patients from Sapienza University Hospital of Rome were divided into four groups: (1) the emergency group (patients with mild forms who were quickly discharged); (2) the hospital ward group (patients that after the admission in the emergency department were hospitalized in a COVID-19 ward); (3) the intensive care unit (ICU) group (patients that after the admission in the emergency department required intensive assistance); (4) the deceased group (patients that after the admission in the emergency department had a fatal outcome). Results: ANOVA and ROC data showed that high-sensitivity troponin-T (TnT), fibrinogen, glycemia, C-reactive protein, lactate dehydrogenase, albumin, D-dimer myoglobin, and ferritin for both men and women may predict lethal outcomes already at the level of the emergency department. Conclusions: Compared to previous Delta COVID-19 parallel emergency patterns of prediction, Omicron-induced changes in TnT may be considered other early predictors of severe outcomes.
2023
omicron; sars-cov-2; biomarkers; blood analyses; morbidity; mortality; variant
01 Pubblicazione su rivista::01a Articolo in rivista
Blood biomarkers from the emergency department disclose severe omicron covid-19-associated outcomes / Pennacchia, Fiorenza; Rusi, Eqrem; Ruqa, Wael Abu; Zingaropoli, Maria Antonella; Pasculli, Patrizia; Talarico, Giuseppina; Bruno, Giuseppe; Barbato, Christian; Minni, Antonio; Tarani, Luigi; Galardo, Gioacchino; Pugliese, Francesco; Lucarelli, Marco; Ferraguti, Giampiero; Ciardi, Maria Rosa; Fiore, Marco. - In: MICROORGANISMS. - ISSN 2076-2607. - 11:4(2023), pp. 1-21. [10.3390/microorganisms11040925]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1679907
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