HIPK2 is an evolutionary conserved protein kinase which modulates many molecular pathways involved in cellular functions such as apoptosis, DNA damage response, protein stability, and protein transcription. HIPK2 plays a key role in the cancer cell response to cytotoxic drugs as its deregulation impairs drug-induced cancer cell death. HIPK2 has also been involved in regulating fibrosis, angiogenesis, and neurological diseases. Recently, hyperglycemia was found to positively and/or negatively regulate HIPK2 activity, affecting not only cancer cell response to chemotherapy but also the progression of some diabetes complications. The present review will discuss how HIPK2 may be influenced by the high glucose (HG) metabolic condition and the consequences of such regulation in medical conditions.

The Sweet Side of HIPK2 / Garufi, Alessia; D'Orazi, Valerio; Pistritto, Giuseppa; Cirone, Mara; D’Orazi, Gabriella. - In: CANCERS. - ISSN 2072-6694. - 15:10(2023). [10.3390/cancers15102678]

The Sweet Side of HIPK2

Valerio D’Orazi
Writing – Review & Editing
;
Mara Cirone
Conceptualization
;
2023

Abstract

HIPK2 is an evolutionary conserved protein kinase which modulates many molecular pathways involved in cellular functions such as apoptosis, DNA damage response, protein stability, and protein transcription. HIPK2 plays a key role in the cancer cell response to cytotoxic drugs as its deregulation impairs drug-induced cancer cell death. HIPK2 has also been involved in regulating fibrosis, angiogenesis, and neurological diseases. Recently, hyperglycemia was found to positively and/or negatively regulate HIPK2 activity, affecting not only cancer cell response to chemotherapy but also the progression of some diabetes complications. The present review will discuss how HIPK2 may be influenced by the high glucose (HG) metabolic condition and the consequences of such regulation in medical conditions.
2023
hyperglycemia; diabetes; p53; apoptosis; drug resistance; HIF-1; hypoxia; microRNA; cancer; diabetic complications
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The Sweet Side of HIPK2 / Garufi, Alessia; D'Orazi, Valerio; Pistritto, Giuseppa; Cirone, Mara; D’Orazi, Gabriella. - In: CANCERS. - ISSN 2072-6694. - 15:10(2023). [10.3390/cancers15102678]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1679272
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