Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG), H3 K27–altered. DMG represents a rare tumor with a dismal prognosis. The diagnosis of DMG is largely based on clinical presentation and characteristic features on conventional magnetic resonance imaging (MRI), with biopsy limited by its delicate neuroanatomic location. Standard MRI remains limited in its ability to characterize tumor biology. Advanced MRI and positron emission tomography (PET) imaging offer additional value as they enable non-invasive evaluation of molecular and metabolic features of brain tumors. These techniques have been widely used for tumor detection, metabolic characterization and treatment response monitoring of brain tumors. However, their role in the realm of pediatric DMG is nascent. By summarizing DMG metabolic pathways in conjunction with their imaging surrogates, we aim to elucidate the untapped potential of such imaging techniques in this devastating disease.

The promise of metabolic imaging in diffuse midline glioma / Lovibond, Samantha; Gewirtz, Alexandra N.; Pasquini, Luca; Krebs, Simone; Graham, Maya S.. - In: NEOPLASIA. - ISSN 1522-8002. - (2023). [10.1016/j.neo.2023.100896]

The promise of metabolic imaging in diffuse midline glioma

Luca Pasquini
Investigation
;
2023

Abstract

Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG), H3 K27–altered. DMG represents a rare tumor with a dismal prognosis. The diagnosis of DMG is largely based on clinical presentation and characteristic features on conventional magnetic resonance imaging (MRI), with biopsy limited by its delicate neuroanatomic location. Standard MRI remains limited in its ability to characterize tumor biology. Advanced MRI and positron emission tomography (PET) imaging offer additional value as they enable non-invasive evaluation of molecular and metabolic features of brain tumors. These techniques have been widely used for tumor detection, metabolic characterization and treatment response monitoring of brain tumors. However, their role in the realm of pediatric DMG is nascent. By summarizing DMG metabolic pathways in conjunction with their imaging surrogates, we aim to elucidate the untapped potential of such imaging techniques in this devastating disease.
2023
diffuse midline glioma; metabolism; pet; mri; imaging
01 Pubblicazione su rivista::01a Articolo in rivista
The promise of metabolic imaging in diffuse midline glioma / Lovibond, Samantha; Gewirtz, Alexandra N.; Pasquini, Luca; Krebs, Simone; Graham, Maya S.. - In: NEOPLASIA. - ISSN 1522-8002. - (2023). [10.1016/j.neo.2023.100896]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1679133
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