The continuous progress in cardiovascular risk prevention strategies has led to an impressive reduction in mortality and recurrent ischemic events in patients with coronary artery disease (CAD). However, the control of several cardiovascular risk factors remains suboptimal in many CAD patients, with a high rate of recurrent events, underlying the need for more new prevention strategies. The GAPS-I (glucagon-like peptide 1 analogues, antithrombotic agents, proprotein convertase subtilisin/kexin type 9 inhibitors, sodium glucose cotransporter type 2 inhibitors and immunomodulators) strategy offers a promising potential in patients with a high-residual cardiovascular risk, who are frequently encountered in daily practice, by offering an individualized and structured approach to addressing their individual risk factors. The current review summarizes the evidence to date on each of its components, with respect to clinical outcomes and economic feasibility. The current evidence points to an efficacy of GAPS-I in reducing major adverse cardiovascular events and mortality, without a compromise on safety, albeit with the need for longer follow-up data.

How to fill the GAPS-I in secondary prevention. Application of a strategy based on GLP1 analogues, antithrombotic agents, PCSK9 inhibitors, SGLT2 inhibitors and immunomodulators / Sabouret, P.; Angoulvant, D.; Pathak, A.; Fysekidis, M.; Laterra, G.; Costa, F.; Angelini, F.; Bocchino, J. P.; Montalescot, G.; Biondi-Zoccai, G.. - In: PANMINERVA MEDICA. - ISSN 0031-0808. - 64:2(2022), pp. 265-273. [10.23736/S0031-0808.21.04284-1]

How to fill the GAPS-I in secondary prevention. Application of a strategy based on GLP1 analogues, antithrombotic agents, PCSK9 inhibitors, SGLT2 inhibitors and immunomodulators

Biondi-Zoccai G.
2022

Abstract

The continuous progress in cardiovascular risk prevention strategies has led to an impressive reduction in mortality and recurrent ischemic events in patients with coronary artery disease (CAD). However, the control of several cardiovascular risk factors remains suboptimal in many CAD patients, with a high rate of recurrent events, underlying the need for more new prevention strategies. The GAPS-I (glucagon-like peptide 1 analogues, antithrombotic agents, proprotein convertase subtilisin/kexin type 9 inhibitors, sodium glucose cotransporter type 2 inhibitors and immunomodulators) strategy offers a promising potential in patients with a high-residual cardiovascular risk, who are frequently encountered in daily practice, by offering an individualized and structured approach to addressing their individual risk factors. The current review summarizes the evidence to date on each of its components, with respect to clinical outcomes and economic feasibility. The current evidence points to an efficacy of GAPS-I in reducing major adverse cardiovascular events and mortality, without a compromise on safety, albeit with the need for longer follow-up data.
2022
cardiology; coronary artery disease; heart disease risk factors
01 Pubblicazione su rivista::01a Articolo in rivista
How to fill the GAPS-I in secondary prevention. Application of a strategy based on GLP1 analogues, antithrombotic agents, PCSK9 inhibitors, SGLT2 inhibitors and immunomodulators / Sabouret, P.; Angoulvant, D.; Pathak, A.; Fysekidis, M.; Laterra, G.; Costa, F.; Angelini, F.; Bocchino, J. P.; Montalescot, G.; Biondi-Zoccai, G.. - In: PANMINERVA MEDICA. - ISSN 0031-0808. - 64:2(2022), pp. 265-273. [10.23736/S0031-0808.21.04284-1]
File allegati a questo prodotto
File Dimensione Formato  
Sabouret_GAPS-I_2022.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 461.42 kB
Formato Adobe PDF
461.42 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1679061
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact