: Functional pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous diseases in terms of both clinical and pathological aspects. These tumors secrete hormones or peptides, which may cause a wide variety of symptoms related to a clinical syndrome. The management of functional pNENs is still challenging for clinicians due to the need to control both tumor growth and specific symptoms. Surgery remains the cornerstone in the management of local disease because it can definitively cure the patient. However, when the disease is not resectable, a broad spectrum of therapeutic options, including locoregional therapy, somatostatin analogs (SSAs), targeted therapies, peptide-receptor radionuclide therapy (PRRT), and chemotherapy, are available. The present review summarizes the main key issues regarding the clinical management of these tumors, providing a specific highlight on their therapeutic approach.

Management of functional pancreatic neuroendocrine neoplasms / Magi, Ludovica; Marasco, Matteo; Rinzivillo, Maria; Faggiano, Antongiulio; Panzuto, Francesco. - In: CURRENT TREATMENT OPTIONS IN ONCOLOGY. - ISSN 1534-6277. - 24:7(2023), pp. 725-741. [10.1007/s11864-023-01085-0]

Management of functional pancreatic neuroendocrine neoplasms

Magi, Ludovica;Marasco, Matteo;Rinzivillo, Maria;Faggiano, Antongiulio;Panzuto, Francesco
2023

Abstract

: Functional pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous diseases in terms of both clinical and pathological aspects. These tumors secrete hormones or peptides, which may cause a wide variety of symptoms related to a clinical syndrome. The management of functional pNENs is still challenging for clinicians due to the need to control both tumor growth and specific symptoms. Surgery remains the cornerstone in the management of local disease because it can definitively cure the patient. However, when the disease is not resectable, a broad spectrum of therapeutic options, including locoregional therapy, somatostatin analogs (SSAs), targeted therapies, peptide-receptor radionuclide therapy (PRRT), and chemotherapy, are available. The present review summarizes the main key issues regarding the clinical management of these tumors, providing a specific highlight on their therapeutic approach.
2023
gastrinoma; insulinoma; neuroendocrine tumors; somatostatin analogs; treatment
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Management of functional pancreatic neuroendocrine neoplasms / Magi, Ludovica; Marasco, Matteo; Rinzivillo, Maria; Faggiano, Antongiulio; Panzuto, Francesco. - In: CURRENT TREATMENT OPTIONS IN ONCOLOGY. - ISSN 1534-6277. - 24:7(2023), pp. 725-741. [10.1007/s11864-023-01085-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1678766
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