Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic strategies used to prevent nasal polyp recurrence after surgical treatment. Finally, we report an in vitro study evaluating the efficacy of lysine-acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (ketoprofen and diclofenac) on the proliferation of fibroblasts, obtained from nasal polyp tissue samples. Our study demonstrates that diclofenac, even more so than lysine-acetylsalicylic acid, significantly inhibits fibroblast proliferation and could be considered a valid therapeutic strategy in preventing CRSwNP recurrence.

Therapeutic strategies to prevent the recurrence of nasal polyps after surgical treatment: an update and in vitro study on growth inhibition of fibroblasts / Rizzi, Angela; Gammeri, Luca; Cordiano, Raffaele; Valentini, Mariagrazia; Centrone, Michele; Marrone, Sabino; Inchingolo, Riccardo; Michaela Lohmeyer, Franziska; Cavaliere, Carlo; Ria, Francesco; Cadoni, Gabriella; Gangemi, Sebastiano; Nucera, Eleonora. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:8(2023). [10.3390/jcm12082841]

Therapeutic strategies to prevent the recurrence of nasal polyps after surgical treatment: an update and in vitro study on growth inhibition of fibroblasts

Carlo Cavaliere;
2023

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic strategies used to prevent nasal polyp recurrence after surgical treatment. Finally, we report an in vitro study evaluating the efficacy of lysine-acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (ketoprofen and diclofenac) on the proliferation of fibroblasts, obtained from nasal polyp tissue samples. Our study demonstrates that diclofenac, even more so than lysine-acetylsalicylic acid, significantly inhibits fibroblast proliferation and could be considered a valid therapeutic strategy in preventing CRSwNP recurrence.
2023
chronic rhinosinusitis with nasal polyps; surgical polypectomy; intranasal corticosteroids; non-steroidal anti-inflammatory drugs; lysine-acetylsalicylate; diclofenac; ketoprofen; fibroblast; proliferation; biological therapies
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Therapeutic strategies to prevent the recurrence of nasal polyps after surgical treatment: an update and in vitro study on growth inhibition of fibroblasts / Rizzi, Angela; Gammeri, Luca; Cordiano, Raffaele; Valentini, Mariagrazia; Centrone, Michele; Marrone, Sabino; Inchingolo, Riccardo; Michaela Lohmeyer, Franziska; Cavaliere, Carlo; Ria, Francesco; Cadoni, Gabriella; Gangemi, Sebastiano; Nucera, Eleonora. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:8(2023). [10.3390/jcm12082841]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1678375
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