While most patients with hypertrophic cardiomyopathy (HCM) show a relatively stable morphologic and clinical phenotype, in some others, progressive changes in the left ventricular (LV) wall thickness, cavity size, and function, defined, overall, as "LV remodeling", may occur. The interplay of multiple pathophysiologic mechanisms, from genetic background to myocardial ischemia and fibrosis, is implicated in this process. Different patterns of LV remodeling have been recognized and are associated with a specific impact on the clinical course and management of the disease. These findings underline the need for and the importance of serial multimodal clinical and instrumental evaluations to identify and further characterize the LV remodeling phenomenon. A more complete definition of the stages of the disease may present a chance to improve the management of HCM patients.

Left ventricular remodeling in hypertrophic cardiomyopathy: an overview of current knowledge / Musumeci, Beatrice; Tini, Giacomo; Russo, Domitilla; Sclafani, Matteo; Cava, Francesco; Tropea, Alessandro; Adduci, Carmen; Palano, Francesca; Francia, Pietro; Autore, Camillo. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:8(2021), pp. 1-12. [10.3390/jcm10081547]

Left ventricular remodeling in hypertrophic cardiomyopathy: an overview of current knowledge

Musumeci, Beatrice;Tini, Giacomo;Russo, Domitilla;Sclafani, Matteo;Cava, Francesco;Tropea, Alessandro;Adduci, Carmen;Palano, Francesca;Francia, Pietro;Autore, Camillo
2021

Abstract

While most patients with hypertrophic cardiomyopathy (HCM) show a relatively stable morphologic and clinical phenotype, in some others, progressive changes in the left ventricular (LV) wall thickness, cavity size, and function, defined, overall, as "LV remodeling", may occur. The interplay of multiple pathophysiologic mechanisms, from genetic background to myocardial ischemia and fibrosis, is implicated in this process. Different patterns of LV remodeling have been recognized and are associated with a specific impact on the clinical course and management of the disease. These findings underline the need for and the importance of serial multimodal clinical and instrumental evaluations to identify and further characterize the LV remodeling phenomenon. A more complete definition of the stages of the disease may present a chance to improve the management of HCM patients.
2021
end stage; hypertrophic cardiomyopathy; left ventricular remodeling; risk stratification
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Left ventricular remodeling in hypertrophic cardiomyopathy: an overview of current knowledge / Musumeci, Beatrice; Tini, Giacomo; Russo, Domitilla; Sclafani, Matteo; Cava, Francesco; Tropea, Alessandro; Adduci, Carmen; Palano, Francesca; Francia, Pietro; Autore, Camillo. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:8(2021), pp. 1-12. [10.3390/jcm10081547]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1678308
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