Background and Methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals. Results: We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome. Conclusions: Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men.

COVID-19 affects serum brain-derived neurotrophic factor and neurofilament light chain in aged men. Implications for morbidity and mortality / Petrella, C.; Zingaropoli, M. A.; Ceci, F. M.; Pasculli, P.; Latronico, T.; Liuzzi, G. M.; Ciardi, M. R.; Angeloni, A.; Ettorre, E.; Menghi, M.; Barbato, C.; Ferraguti, G.; Minni, A.; Fiore, M.. - In: CELLS. - ISSN 2073-4409. - 12:4(2023), pp. 1-16. [10.3390/cells12040655]

COVID-19 affects serum brain-derived neurotrophic factor and neurofilament light chain in aged men. Implications for morbidity and mortality

Zingaropoli M. A.;Ceci F. M.;Pasculli P.;Ciardi M. R.;Angeloni A.;Ettorre E.;Ferraguti G.;Minni A.;
2023

Abstract

Background and Methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals. Results: We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome. Conclusions: Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men.
2023
bdnf; covid-19; mmp-2; mmp-9; nfl; ngf; neurocovid; aging
01 Pubblicazione su rivista::01a Articolo in rivista
COVID-19 affects serum brain-derived neurotrophic factor and neurofilament light chain in aged men. Implications for morbidity and mortality / Petrella, C.; Zingaropoli, M. A.; Ceci, F. M.; Pasculli, P.; Latronico, T.; Liuzzi, G. M.; Ciardi, M. R.; Angeloni, A.; Ettorre, E.; Menghi, M.; Barbato, C.; Ferraguti, G.; Minni, A.; Fiore, M.. - In: CELLS. - ISSN 2073-4409. - 12:4(2023), pp. 1-16. [10.3390/cells12040655]
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Note: COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1677819
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