Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Incidence of liver cancer has been increasing in recent years, and the 5-year survival is <20%. HCC and CCA are often accompanied with a dense stroma coupled with infiltrated immune cells, which is referred to as the tumor microenvironment. Populations of specific immune cells, such as high density of CD163+ macrophages and low density of CD8+ T cells, are associated with prognosis and survival rates in both HCC and CCA. Immune cells in the tumor microenvironment can be a therapeutic target for liver cancer treatments. Previous studies have introduced immunotherapy using immune checkpoint inhibitors, pulsed dendritic cells, or transduced T cells, to enhance cytotoxicity of immune cells and inhibit tumor growth. This review summarizes current understanding of the roles of immune cells in primary liver cancer covering HCC and CCA. (Am J Pathol 2022, 192: 826-836; https://doi.org/10.1016/ j.ajpath.2022.02.004)

The functional roles of immune cells in primary liver cancer / Pham, Linh; Kyritsi, Konstantina; Zhou, Tianhao; Ceci, Ludovica; Baiocchi, Leonardo; Kennedy, Lindsey; Chakraborty, Sanjukta; Glaser, Shannon; Francis, Heather; Alpini, Gianfranco; Sato, Keisaku. - In: THE AMERICAN JOURNAL OF PATHOLOGY. - ISSN 0002-9440. - 192:6(2022), pp. 826-836. [10.1016/j.ajpath.2022.02.004]

The functional roles of immune cells in primary liver cancer

Ceci, Ludovica;Alpini, Gianfranco;
2022

Abstract

Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Incidence of liver cancer has been increasing in recent years, and the 5-year survival is <20%. HCC and CCA are often accompanied with a dense stroma coupled with infiltrated immune cells, which is referred to as the tumor microenvironment. Populations of specific immune cells, such as high density of CD163+ macrophages and low density of CD8+ T cells, are associated with prognosis and survival rates in both HCC and CCA. Immune cells in the tumor microenvironment can be a therapeutic target for liver cancer treatments. Previous studies have introduced immunotherapy using immune checkpoint inhibitors, pulsed dendritic cells, or transduced T cells, to enhance cytotoxicity of immune cells and inhibit tumor growth. This review summarizes current understanding of the roles of immune cells in primary liver cancer covering HCC and CCA. (Am J Pathol 2022, 192: 826-836; https://doi.org/10.1016/ j.ajpath.2022.02.004)
2022
immune cells; liver diseases; cancer
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The functional roles of immune cells in primary liver cancer / Pham, Linh; Kyritsi, Konstantina; Zhou, Tianhao; Ceci, Ludovica; Baiocchi, Leonardo; Kennedy, Lindsey; Chakraborty, Sanjukta; Glaser, Shannon; Francis, Heather; Alpini, Gianfranco; Sato, Keisaku. - In: THE AMERICAN JOURNAL OF PATHOLOGY. - ISSN 0002-9440. - 192:6(2022), pp. 826-836. [10.1016/j.ajpath.2022.02.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1677694
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