Introduction The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. Methods The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. Results In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. Conclusions The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research.
The Italian tremor Network (TITAN): rationale, design and preliminary findings / Erro, Roberto; Pilotto, Andrea; Esposito, Marcello; Olivola, Enrica; Nicoletti, Alessandra; Lazzeri, Giulia; Magistrelli, Luca; Dallocchio, Carlo; Marchese, Roberta; Bologna, Matteo; Tessitore, Alessandro; Misceo, Salvatore; Gigante, Angelo Fabio; Terranova, Carmen; Moschella, Vincenzo; di Biase, Lazzaro; Di Giacopo, Raffaella; Morgante, Francesca; Valentino, Francesca; De Rosa, Anna; Trinchillo, Assunta; Malaguti, Maria Chiara; Brusa, Livia; Matinella, Angela; Di Biasio, Francesca; Paparella, Giulia; De Micco, Rosa; Contaldi, Elena; Modugno, Nicola; Di Fonzo, Alessio; Padovani, Alessandro; Barone, Paolo. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 43:9(2022), pp. 5369-5376. [10.1007/s10072-022-06104-w]
The Italian tremor Network (TITAN): rationale, design and preliminary findings
Bologna, Matteo;Morgante, Francesca;Di Biasio, Francesca;Paparella, Giulia;Modugno, Nicola;Barone, Paolo
2022
Abstract
Introduction The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. Methods The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. Results In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. Conclusions The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research.File | Dimensione | Formato | |
---|---|---|---|
2022 erro_titan.pdf
accesso aperto
Note: Erro_The Italian tremor Network (TITAN)_2022
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
480.41 kB
Formato
Adobe PDF
|
480.41 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.