Reactive oxygen species (ROS) is a term that defines a group of unstable compounds derived from exogenous sources or endogenous metabolism. Under physiological conditions, low levels of ROS play a key role in the regulation of signal transduction- or transcription-mediated cellular responses. In contrast, excessive and uncontrolled loading of ROS results in a pathological state known as oxidative stress (OS), a leading contributor to aging and a pivotal factor for the onset and progression of many disorders. Evolution has endowed cells with an antioxidant system involved in stabilizing ROS levels to a specific threshold, maintaining ROS-induced signalling function and limiting negative side effects. In mammals, a great deal of evidence indicates that females defence against ROS is more proficient than males, determining a longer lifespan and lower incidence of most chronic diseases. In this review, we will summarize the most recent sex-related differences in the regulation of redox homeostasis. We will highlight the peculiar aspects of the antioxidant defence in sex-biased diseases whose onset or progression is driven by OS, and we will discuss the molecular, genetic, and evolutionary determinants of female proficiency to cope with ROS.

Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology / Tiberi, Jessica; Cesarini, Valeriana; Stefanelli, Roberta; Canterini, Sonia; Fiorenza, Maria Teresa; La Rosa, Piergiorgio. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - 211:(2023). [10.1016/j.mad.2023.111802]

Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology

Tiberi, Jessica;Stefanelli, Roberta;Canterini, Sonia;Fiorenza, Maria Teresa;La Rosa, Piergiorgio
2023

Abstract

Reactive oxygen species (ROS) is a term that defines a group of unstable compounds derived from exogenous sources or endogenous metabolism. Under physiological conditions, low levels of ROS play a key role in the regulation of signal transduction- or transcription-mediated cellular responses. In contrast, excessive and uncontrolled loading of ROS results in a pathological state known as oxidative stress (OS), a leading contributor to aging and a pivotal factor for the onset and progression of many disorders. Evolution has endowed cells with an antioxidant system involved in stabilizing ROS levels to a specific threshold, maintaining ROS-induced signalling function and limiting negative side effects. In mammals, a great deal of evidence indicates that females defence against ROS is more proficient than males, determining a longer lifespan and lower incidence of most chronic diseases. In this review, we will summarize the most recent sex-related differences in the regulation of redox homeostasis. We will highlight the peculiar aspects of the antioxidant defence in sex-biased diseases whose onset or progression is driven by OS, and we will discuss the molecular, genetic, and evolutionary determinants of female proficiency to cope with ROS.
2023
Antioxidant defence; Gender; NRF2; Oxidative Stress; Sex-differences
01 Pubblicazione su rivista::01a Articolo in rivista
Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology / Tiberi, Jessica; Cesarini, Valeriana; Stefanelli, Roberta; Canterini, Sonia; Fiorenza, Maria Teresa; La Rosa, Piergiorgio. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - 211:(2023). [10.1016/j.mad.2023.111802]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1677288
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