Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids / Marsee, A.; Roos, F. J. M.; Verstegen, M. M. A.; Roos, F.; Verstegen, M.; Clevers, H.; Vallier, L.; Takebe, T.; Huch, M.; Peng, W. C.; Forbes, S.; Lemaigre, F.; de Koning, E.; Gehart, H.; van der Laan, L.; Spee, B.; Boj, S.; Baptista, P.; Schneeberger, K.; Soroka, C.; Heim, M.; Nuciforo, S.; Zaret, K.; Saito, Y.; Lutolf, M.; Cardinale, V.; Simons, B.; van IJzendoorn, S.; Kamiya, A.; Chikada, H.; Wang, S.; Mun, S. J.; Son, M. J.; Onder, T. T.; Boyer, J.; Sato, T.; Georgakopoulos, N.; Meneses, A.; Broutier, L.; Boulter, L.; Grun, D.; Ijzermans, J.; Artegiani, B.; van Boxtel, R.; Kuijk, E.; Carpino, G.; Peltz, G.; Banales, J.; Man, N.; Aloia, L.; Larusso, N.; George, G.; Rimland, C.; Yeoh, G.; Grappin-Botton, A.; Stange, D.; Prior, N.; Tirnitz-Parker, J. E. E.; Andersson, E.; Braconi, C.; Hannan, N.; Lu, W. -Y.; Strom, S.; Sancho-Bru, P.; Ogawa, S.; Corbo, V.; Lancaster, M.; Hu, H.; Fuchs, S.; Hendriks, D.; Forbes, S. J.; van der Laan, L. J. W.. - In: CELL STEM CELL. - ISSN 1934-5909. - 28:5(2021), pp. 816-832. [10.1016/j.stem.2021.04.005]

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Cardinale V.;Carpino G.;
2021

Abstract

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.
2021
bile duct; delphi method; epithelial organoid; gallbladder; HPB; liver; multi-organ organoid; multi-tissue organoid; pancreas; tumor organoid
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids / Marsee, A.; Roos, F. J. M.; Verstegen, M. M. A.; Roos, F.; Verstegen, M.; Clevers, H.; Vallier, L.; Takebe, T.; Huch, M.; Peng, W. C.; Forbes, S.; Lemaigre, F.; de Koning, E.; Gehart, H.; van der Laan, L.; Spee, B.; Boj, S.; Baptista, P.; Schneeberger, K.; Soroka, C.; Heim, M.; Nuciforo, S.; Zaret, K.; Saito, Y.; Lutolf, M.; Cardinale, V.; Simons, B.; van IJzendoorn, S.; Kamiya, A.; Chikada, H.; Wang, S.; Mun, S. J.; Son, M. J.; Onder, T. T.; Boyer, J.; Sato, T.; Georgakopoulos, N.; Meneses, A.; Broutier, L.; Boulter, L.; Grun, D.; Ijzermans, J.; Artegiani, B.; van Boxtel, R.; Kuijk, E.; Carpino, G.; Peltz, G.; Banales, J.; Man, N.; Aloia, L.; Larusso, N.; George, G.; Rimland, C.; Yeoh, G.; Grappin-Botton, A.; Stange, D.; Prior, N.; Tirnitz-Parker, J. E. E.; Andersson, E.; Braconi, C.; Hannan, N.; Lu, W. -Y.; Strom, S.; Sancho-Bru, P.; Ogawa, S.; Corbo, V.; Lancaster, M.; Hu, H.; Fuchs, S.; Hendriks, D.; Forbes, S. J.; van der Laan, L. J. W.. - In: CELL STEM CELL. - ISSN 1934-5909. - 28:5(2021), pp. 816-832. [10.1016/j.stem.2021.04.005]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1677279
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 66
  • Scopus 119
  • ???jsp.display-item.citation.isi??? 110
social impact